Mouse Monoclonal Anti-Human IgM antibody (STJ99249)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-Human IgM antibody (STJ99249)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|AGM1 antibody|Constant region of heavy chain of IgM antibody|DKFZp686I15196 antibody|DKFZp686I15212 antibody|FLJ00385 antibody|Hepatitis B virus receptor binding protein antibody|Ig mu chain C region antibody|IGHM antibody|IgM heavy chain constant region antibody|Immunoglobulin heavy constant mu antibody|Immunoglobulin mu chain antibody|Imunoglobulin heavy chain antibody|Imunoglobulin heavy chain constant region mu antibody|Imunoglobulin heavy chain mu constant region antibody|MGC104996 antibody|MGC52291 antibody|MU antibody|VH antibody|Anti-IgM antibody [UCH-B1] (ab18201)
SCBT cat No: sc-51993|sc-51990|sc-51991|sc-71326|sc-271913|sc-51992|sc-168131|sc-514782|sc-53853|sc-53081|sc-53345|sc-53082|sc-393519|

Name

Anti-Human IgM antibody

Catalogue No.

STJ99249

Reactivity

Human

Specificity

Anti-Human IgM antibody detects human IgM proteins.

Immunogen

Purified recombinant full length of human IgM heavy chain protein expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Molecular weight

75kDa

Formulation

Anti-Human IgM antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Human IgM antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

AGM1 antibody, Constant region of heavy chain of IgM antibody, DKFZp686I15196 antibody, DKFZp686I15212 antibody, FLJ00385 antibody, Hepatitis B virus receptor binding protein antibody, Ig mu chain C region antibody, IGHM antibody, IgM heavy chain constant region antibody, Immunoglobulin heavy constant mu antibody, Immunoglobulin mu chain antibody, Imunoglobulin heavy chain antibody, Imunoglobulin heavy chain constant region mu antibody, Imunoglobulin heavy chain mu constant region antibody, MGC104996 antibody, MGC52291 antibody, MU antibody, VH antibody

Database links

UniProt/Swiss-Prot:P01871

Protein function

IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. .

Involvement in disease

Agammaglobulinemia 1, autosomal recessive (AGM1) [MIM:601495]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein cellular localization

Isoform 1: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.; Isoform 2: Cell membrane; Single-pass type I membrane protein.

Research area

All research areas>Lymphocyte Signaling>Immunoglobulin
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize Anti-Human IgM antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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