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Mouse Monoclonal Anti-IMP3 antibody (STJ99190)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-IMP3 antibody.
Check alternative names for the antibodyExpand
|Cancer/testis antigen 98 antibody|CT98 antibody|DKFZp686F1078 antibody|hKOC antibody|IF2B3_HUMAN antibody|IGF II mRNA binding protein 3 antibody|IGF-II mRNA-binding protein 3 antibody|IGF2 mRNA binding protein 3 antibody|IGF2 mRNA-binding protein 3 antibody|IGF2BP3 antibody|IMP 3 antibody|IMP-3 antibody|Insulin like growth factor 2 mRNA binding protein 3 antibody|Insulin-like growth factor 2 mRNA-binding protein 3 antibody|KH domain containing protein overexpressed in cancer antibody|KH domain-containing protein overexpressed in cancer antibody|KOC 1 antibody|KOC1 antibody|VICKZ 3 antibody|VICKZ family member 3 antibody|VICKZ3 antibody|Anti-IMP3 antibody [EPR12021] (ab177477)
SCBT cat No: sc-365641|sc-390639|sc-100766|sc-365640|sc-366419|sc-376067|sc-292451|
|Catalogue No.|| |
Anti-IMP3 antibody detects endogenous levels of IMP3 and does not cross-react with related proteins.
Purified recombinant human IMP3 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-IMP3 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-IMP3 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cancer/testis antigen 98 antibody, CT98 antibody, DKFZp686F1078 antibody, hKOC antibody, IF2B3_HUMAN antibody, IGF II mRNA binding protein 3 antibody, IGF-II mRNA-binding protein 3 antibody, IGF2 mRNA binding protein 3 antibody, IGF2 mRNA-binding protein 3 antibody, IGF2BP3 antibody, IMP 3 antibody, IMP-3 antibody, Insulin like growth factor 2 mRNA binding protein 3 antibody, Insulin-like growth factor 2 mRNA-binding protein 3 antibody, KH domain containing protein overexpressed in cancer antibody, KH domain-containing protein overexpressed in cancer antibody, KOC 1 antibody, KOC1 antibody, VICKZ 3 antibody, VICKZ family member 3 antibody, VICKZ3 antibody
|Database links|| |
|Protein function|| |
RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript ‘caging’ into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3′-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5′-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. .
|Protein tissue specificity|| |
Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines. .
|Protein sequence and domain|| |
Belongs to the RRM IMP/VICKZ family. ; Contains 4 KH domains. ; Contains 2 RRM (RNA recognition motif) domains. All KH domains contribute binding to target mRNA. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.
|Protein cellular localization|| |
Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.
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St John’s Laboratory Ltd.
|Product type|| |
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