Mouse Monoclonal Anti-IMP3 antibody (STJ99190)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-IMP3 antibody (STJ99190)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|Cancer/testis antigen 98 antibody|CT98 antibody|DKFZp686F1078 antibody|hKOC antibody|IF2B3_HUMAN antibody|IGF II mRNA binding protein 3 antibody|IGF-II mRNA-binding protein 3 antibody|IGF2 mRNA binding protein 3 antibody|IGF2 mRNA-binding protein 3 antibody|IGF2BP3 antibody|IMP 3 antibody|IMP-3 antibody|Insulin like growth factor 2 mRNA binding protein 3 antibody|Insulin-like growth factor 2 mRNA-binding protein 3 antibody|KH domain containing protein overexpressed in cancer antibody|KH domain-containing protein overexpressed in cancer antibody|KOC 1 antibody|KOC1 antibody|VICKZ 3 antibody|VICKZ family member 3 antibody|VICKZ3 antibody|Anti-IMP3 antibody [EPR12021] (ab177477)
SCBT cat No: sc-365641|sc-390639|sc-100766|sc-365640|sc-366419|sc-376067|sc-292451|

Name

Anti-IMP3 antibody

Catalogue No.

STJ99190

Reactivity

Human

Specificity

Anti-IMP3 antibody detects endogenous levels of IMP3 and does not cross-react with related proteins.

Immunogen

Purified recombinant human IMP3 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

70kDa

Formulation

Anti-IMP3 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-IMP3 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Cancer/testis antigen 98 antibody, CT98 antibody, DKFZp686F1078 antibody, hKOC antibody, IF2B3_HUMAN antibody, IGF II mRNA binding protein 3 antibody, IGF-II mRNA-binding protein 3 antibody, IGF2 mRNA binding protein 3 antibody, IGF2 mRNA-binding protein 3 antibody, IGF2BP3 antibody, IMP 3 antibody, IMP-3 antibody, Insulin like growth factor 2 mRNA binding protein 3 antibody, Insulin-like growth factor 2 mRNA-binding protein 3 antibody, KH domain containing protein overexpressed in cancer antibody, KH domain-containing protein overexpressed in cancer antibody, KOC 1 antibody, KOC1 antibody, VICKZ 3 antibody, VICKZ family member 3 antibody, VICKZ3 antibody

Database links

UniProt/Swiss-Prot:O00425

Protein function

RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript ‘caging’ into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3′-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5′-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. .

Protein tissue specificity

Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines. .

Protein sequence and domain

Belongs to the RRM IMP/VICKZ family. ; Contains 4 KH domains. ; Contains 2 RRM (RNA recognition motif) domains. All KH domains contribute binding to target mRNA. They are also required for RNA-dependent homo- and heterooligomerization. The integrity of KH domains seems not to be required for localization to stress granules.

Protein cellular localization

Nucleus. Cytoplasm. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. Colocalized with CD44 mRNA in RNP granules. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Note

AntibodyPlus can customize Anti-IMP3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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