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Mouse Monoclonal Anti-Jak1 antibody (STJ99138)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Jak1 antibody.
Check alternative names for the antibodyExpand
|JAK 1 antibody|JAK 1A antibody|JAK 1B antibody|JAK-1 antibody|JAK1 antibody|JAK1_HUMAN antibody|JAK1A antibody|JAK1B antibody|Janus kinase 1 (a protein tyrosine kinase) antibody|Janus kinase 1 antibody|JTK3 antibody|Tyrosine protein kinase JAK 1 antibody|Tyrosine protein kinase JAK1 antibody|Tyrosine-protein kinase JAK1 antibody|Phospho anti-JAK1 (Y1022 + Y1023) antibody [EPR1899(2)] (ab138005)
SCBT cat No: sc-136225|sc-1677|sc-376996|sc-7228|sc-277|sc-295|sc-390539|sc-34479|
|Catalogue No.|| |
Anti-Jak1 antibody detects endogenous levels of Jak1 and does not cross-react with related proteins.
Purified recombinant human Jak1 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Jak1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Jak1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
JAK 1 antibody, JAK 1A antibody, JAK 1B antibody, JAK-1 antibody, JAK1 antibody, JAK1_HUMAN antibody, JAK1A antibody, JAK1B antibody, Janus kinase 1 (a protein tyrosine kinase) antibody, Janus kinase 1 antibody, JTK3 antibody, Tyrosine protein kinase JAK 1 antibody, Tyrosine protein kinase JAK1 antibody, Tyrosine-protein kinase JAK1 antibody
|Database links|| |
|Protein function|| |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529). .
|Protein tissue specificity|| |
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. .
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. ; Contains 1 FERM domain. ; Contains 2 protein kinase domains. ; Contains 1 SH2 domain. Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1. ; The FERM domain mediates interaction with JAKMIP1.
|Protein post-translational modifications|| |
Autophosphorylated (PubMed:7615558). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529). .
|Protein cellular localization|| |
Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/JAK/">JAK</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"> (View all antibody categories related to Kinases and Phosphatases)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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