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Mouse Monoclonal Anti-JNK1 antibody (STJ99225)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-JNK1 antibody.
Check alternative names for the antibodyExpand
|AI849689 antibody|c Jun N terminal kinase 1 antibody|C-JUN kinase 1 antibody|c-Jun N-terminal kinase 1 antibody|EC 18.104.22.168 antibody|JNK 1 antibody|JNK antibody|JNK-46 antibody|JNK1A2 antibody|JNK21B1/2 antibody|MAP kinase 8 antibody|MAPK 8 antibody|mapk8 antibody|Mitogen activated protein kinase 8 antibody|Mitogen-activated protein kinase 8 antibody|MK08_HUMAN antibody|p54 gamma antibody|Prkm8 antibody|Protein kinase JNK1 antibody|Protein kinase, mitogen-activated, 8 antibody|SAPK 1 antibody|SAPK gamma antibody|SAPK1 antibody|Stress-activated protein kinase 1 antibody|Stress-activated protein kinase JNK1 antibody|Phospho anti-JNK1 (T183) antibody (ab47337)
SCBT cat No: sc-1648|
|Catalogue No.|| |
Human, Mouse, Rat
Anti-JNK1 antibody detects endogenous levels of JNK1 and does not cross-react with related proteins.
Purified recombinant human JNK1 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-JNK1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-JNK1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
AI849689 antibody, c Jun N terminal kinase 1 antibody, C-JUN kinase 1 antibody, c-Jun N-terminal kinase 1 antibody, EC 22.214.171.124 antibody, JNK 1 antibody, JNK antibody, JNK-46 antibody, JNK1A2 antibody, JNK21B1/2 antibody, MAP kinase 8 antibody, MAPK 8 antibody, mapk8 antibody, Mitogen activated protein kinase 8 antibody, Mitogen-activated protein kinase 8 antibody, MK08_HUMAN antibody, p54 gamma antibody, Prkm8 antibody, Protein kinase JNK1 antibody, Protein kinase, mitogen-activated, 8 antibody, SAPK 1 antibody, SAPK gamma antibody, SAPK1 antibody, Stress-activated protein kinase 1 antibody, Stress-activated protein kinase JNK1 antibody
|Database links|| |
|Protein function|| |
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). .; JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. ; Contains 1 protein kinase domain. The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
|Protein post-translational modifications|| |
Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Phosphorylated by TAOK2. .
|Protein cellular localization|| |
Cytoplasm . Nucleus .
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/JNK/">JNK</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"> (View all antibody categories related to Kinases and Phosphatases)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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