Mouse Monoclonal Anti-KDM1/LSD1 antibody (STJ99025)

$99.00$319.00

Reactivity: Human, Monkey
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-KDM1/LSD1 antibody (STJ99025)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|Amine oxidase (flavin containing) domain 2 antibody|Amine oxidase, flavin containing, 2 antibody|AOF2 antibody|BHC110 antibody|BRAF35 HDAC complex protein BHC110 antibody|BRAF35-HDAC complex protein BHC110 antibody|BRAF35/HDAC complex, 110-kD subunit antibody|CPRF antibody|EC1 antibody|FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody|Flavin-containing amine oxidase domain-containing protein 2 antibody|KDM 1 antibody|KDM1 antibody|Kdm1a antibody|KDM1A_HUMAN antibody|KIAA0601 antibody|LSD 1 antibody|LSD1 antibody|Lysine (K) specific demethylase 1 antibody|Lysine (K) specific demethylase 1A antibody|Lysine demethylase 1A antibody|Lysine specific histone demethylase 1 antibody|Lysine specific histone demethylase 1A antibody|Lysine-specific demethylase 1 antibody|Lysine-specific demethylase 1A antibody|Lysine-specific histone demethylase 1A antibody|Anti-KDM1 / LSD1 antibody – ChIP Grade (ab17721)
SCBT cat No: sc-53875|sc-136174|sc-271720|sc-67272|sc-49294|

Name

Anti-KDM1/LSD1 antibody

Catalogue No.

STJ99025

Reactivity

Human, Monkey

Specificity

Anti-KDM1/LSD1 antibody detects endogenous levels of KDM1/LSD1 and does not cross-react with related proteins.

Immunogen

Purified recombinant human KDM1/LSD1 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

110kDa

Formulation

Anti-KDM1/LSD1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-KDM1/LSD1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Amine oxidase (flavin containing) domain 2 antibody, Amine oxidase, flavin containing, 2 antibody, AOF2 antibody, BHC110 antibody, BRAF35 HDAC complex protein BHC110 antibody, BRAF35-HDAC complex protein BHC110 antibody, BRAF35/HDAC complex, 110-kD subunit antibody, CPRF antibody, EC1 antibody, FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody, Flavin-containing amine oxidase domain-containing protein 2 antibody, KDM 1 antibody, KDM1 antibody, Kdm1a antibody, KDM1A_HUMAN antibody, KIAA0601 antibody, LSD 1 antibody, LSD1 antibody, Lysine (K) specific demethylase 1 antibody, Lysine (K) specific demethylase 1A antibody, Lysine demethylase 1A antibody, Lysine specific histone demethylase 1 antibody, Lysine specific histone demethylase 1A antibody, Lysine-specific demethylase 1 antibody, Lysine-specific demethylase 1A antibody, Lysine-specific histone demethylase 1A antibody

Database links

UniProt/Swiss-Prot:O60341

Protein function

Histone demethylase that demethylates both ‘Lys-4’ (H3K4me) and ‘Lys-9’ (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of ‘Thr-6’ of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated ‘Lys-370’ of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. .

Protein tissue specificity

Ubiquitously expressed. .

Involvement in disease

Cleft palate, psychomotor retardation, and distinctive facial features (CPRF) [MIM:616728]: A syndrome characterized by cleft palate, developmental delay, psychomotor retardation, and facial dysmorphic features including a prominent forehead, slightly arched eyebrows, elongated palpebral fissures, a wide nasal bridge, thin lips, and widely spaced teeth. Cleft palate is a congenital fissure of the soft and/or hard palate, due to faulty fusion. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the flavin monoamine oxidase family. ; Contains 1 SWIRM domain. The SWIRM domain may act as an anchor site for a histone tail.

Protein cellular localization

Nucleus .

Research area

All research areas>Transcription Regulators>LSD1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Anti-KDM1/LSD1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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