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Mouse Monoclonal Anti-KDM1/LSD1 antibody (STJ99025)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-KDM1/LSD1 antibody.
Check alternative names for the antibodyExpand
|Amine oxidase (flavin containing) domain 2 antibody|Amine oxidase, flavin containing, 2 antibody|AOF2 antibody|BHC110 antibody|BRAF35 HDAC complex protein BHC110 antibody|BRAF35-HDAC complex protein BHC110 antibody|BRAF35/HDAC complex, 110-kD subunit antibody|CPRF antibody|EC1 antibody|FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody|Flavin-containing amine oxidase domain-containing protein 2 antibody|KDM 1 antibody|KDM1 antibody|Kdm1a antibody|KDM1A_HUMAN antibody|KIAA0601 antibody|LSD 1 antibody|LSD1 antibody|Lysine (K) specific demethylase 1 antibody|Lysine (K) specific demethylase 1A antibody|Lysine demethylase 1A antibody|Lysine specific histone demethylase 1 antibody|Lysine specific histone demethylase 1A antibody|Lysine-specific demethylase 1 antibody|Lysine-specific demethylase 1A antibody|Lysine-specific histone demethylase 1A antibody|Anti-KDM1 / LSD1 antibody – ChIP Grade (ab17721)
SCBT cat No: sc-53875|sc-136174|sc-271720|sc-67272|sc-49294|
|Catalogue No.|| |
Anti-KDM1/LSD1 antibody detects endogenous levels of KDM1/LSD1 and does not cross-react with related proteins.
Purified recombinant human KDM1/LSD1 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-KDM1/LSD1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-KDM1/LSD1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Amine oxidase (flavin containing) domain 2 antibody, Amine oxidase, flavin containing, 2 antibody, AOF2 antibody, BHC110 antibody, BRAF35 HDAC complex protein BHC110 antibody, BRAF35-HDAC complex protein BHC110 antibody, BRAF35/HDAC complex, 110-kD subunit antibody, CPRF antibody, EC1 antibody, FAD binding protein BRAF35 HDAC complex, 110 kDa subunit antibody, Flavin-containing amine oxidase domain-containing protein 2 antibody, KDM 1 antibody, KDM1 antibody, Kdm1a antibody, KDM1A_HUMAN antibody, KIAA0601 antibody, LSD 1 antibody, LSD1 antibody, Lysine (K) specific demethylase 1 antibody, Lysine (K) specific demethylase 1A antibody, Lysine demethylase 1A antibody, Lysine specific histone demethylase 1 antibody, Lysine specific histone demethylase 1A antibody, Lysine-specific demethylase 1 antibody, Lysine-specific demethylase 1A antibody, Lysine-specific histone demethylase 1A antibody
|Database links|| |
|Protein function|| |
Histone demethylase that demethylates both ‘Lys-4’ (H3K4me) and ‘Lys-9’ (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of ‘Thr-6’ of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated ‘Lys-370’ of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. .
|Protein tissue specificity|| |
Ubiquitously expressed. .
|Involvement in disease|| |
Cleft palate, psychomotor retardation, and distinctive facial features (CPRF) [MIM:616728]: A syndrome characterized by cleft palate, developmental delay, psychomotor retardation, and facial dysmorphic features including a prominent forehead, slightly arched eyebrows, elongated palpebral fissures, a wide nasal bridge, thin lips, and widely spaced teeth. Cleft palate is a congenital fissure of the soft and/or hard palate, due to faulty fusion. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the flavin monoamine oxidase family. ; Contains 1 SWIRM domain. The SWIRM domain may act as an anchor site for a histone tail.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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