Mouse Monoclonal Anti-KDM5C/Jarid1C/SMCX antibody (STJ99023)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-KDM5C/Jarid1C/SMCX antibody (STJ99023)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|DXS1272E antibody|Histone demethylase JARID1C antibody|JARID1C antibody|JmjC domain containing protein SMCX antibody|Jumonji AT rich interactive domain 1C antibody|Jumonji, AT rich interactive domain 1C (RBP2 like) antibody|Jumonji/ARID domain-containing protein 1C antibody|KDM5C antibody|KDM5C_HUMAN antibody|Lysine (K) specific demethylase 5C antibody|Lysine-specific demethylase 5C antibody|MRX13 antibody|MRXJ antibody|MRXSCJ antibody|MRXSJ antibody|Protein SmcX antibody|Protein Xe169 antibody|rbp2 like protein antibody|Selected cDNA on X antibody|SMCX antibody|Smcx homolog X chromosome antibody|SmcX protein antibody|Smcy homolog X linked antibody|XE169 antibody|Xe169 protein antibody|Anti-KDM5C / Jarid1C / SMCX antibody – ChIP Grade (ab34718)
SCBT cat No:

Name

Anti-KDM5C/Jarid1C/SMCX antibody

Catalogue No.

STJ99023

Reactivity

Human

Specificity

Anti-KDM5C/Jarid1C/SMCX antibody detects endogenous levels of KDM5C / Jarid1C / SMCX and does not corss-react with related proteins.

Immunogen

Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Molecular weight

220kDa

Formulation

Anti-KDM5C/Jarid1C/SMCX antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-KDM5C/Jarid1C/SMCX antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

DXS1272E antibody, Histone demethylase JARID1C antibody, JARID1C antibody, JmjC domain containing protein SMCX antibody, Jumonji AT rich interactive domain 1C antibody, Jumonji, AT rich interactive domain 1C (RBP2 like) antibody, Jumonji/ARID domain-containing protein 1C antibody, KDM5C antibody, KDM5C_HUMAN antibody, Lysine (K) specific demethylase 5C antibody, Lysine-specific demethylase 5C antibody, MRX13 antibody, MRXJ antibody, MRXSCJ antibody, MRXSJ antibody, Protein SmcX antibody, Protein Xe169 antibody, rbp2 like protein antibody, Selected cDNA on X antibody, SMCX antibody, Smcx homolog X chromosome antibody, SmcX protein antibody, Smcy homolog X linked antibody, XE169 antibody, Xe169 protein antibody

Database links

UniProt/Swiss-Prot:P41229

Protein function

Histone demethylase that specifically demethylates ‘Lys-4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ‘Lys-9’, H3 ‘Lys-27’, H3 ‘Lys-36’, H3 ‘Lys-79’ or H4 ‘Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ‘Lys-4’. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). .

Protein tissue specificity

Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. .

Involvement in disease

Mental retardation, X-linked, syndromic, Claes-Jensen type (MRXSCJ) [MIM:300534]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSCJ patients manifest mental retardation associated with variable features such as slowly progressive spastic paraplegia, seizures, facial dysmorphism. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the JARID1 histone demethylase family. ; Contains 1 ARID domain. ; Contains 1 JmjC domain. ; Contains 1 JmjN domain. ; Contains 2 PHD-type zinc fingers. The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.; Both the JmjC domain and the JmjN domain are required for enzymatic activity.

Protein cellular localization

Nucleus .

Research area

All research areas>Transcription Regulators>SmcX
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Anti-KDM5C/Jarid1C/SMCX antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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