Mouse Monoclonal Anti-Keratin 18 antibody (STJ99094)

$99.00$319.00

Reactivity: Human, Monkey
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-Keratin 18 antibody (STJ99094)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

|CYK18 antibody|Cell proliferation-inducing gene 46 protein antibody|CK-18 antibody|CK-19 antibody|CK-8 antibody|CYK8 antibody|Cytokeratin-18 antibody|Cytokeratin-19 antibody|Cytokeratin-8 antibody|K19 antibody|K8 antibody|Keratin, type I cytoskeletal 18 antibody|Keratin, type I cytoskeletal 19 antibody|Keratin, type II cytoskeletal 8 antibody|Keratin-18 antibody|Keratin-19 antibody|Keratin-8 antibody|KRT18 antibody|KRT19 antibody|KRT8 antibody|PIG46 antibody|Type-II keratin Kb8 antibody|Anti-Keratin 8+18+19 antibody [2A4] (ab118855)
SCBT cat No: sc-130312|sc-58736|sc-73480|sc-58737|sc-374275|sc-8020|sc-374274|sc-374027|sc-134484|sc-101459|sc-53266|sc-52324|

Name

Anti-Keratin 18 antibody

Catalogue No.

STJ99094

Reactivity

Human, Monkey

Specificity

Anti-Keratin 18 antibody detects endogenous levels of Keratin 18 and does not cross-react with related proteins.

Immunogen

Purified recombinant human Keratin 18 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Molecular weight

46kDa

Formulation

Anti-Keratin 18 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Keratin 18 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

CYK18 antibody, Cell proliferation-inducing gene 46 protein antibody, CK-18 antibody, CK-19 antibody, CK-8 antibody, CYK8 antibody, Cytokeratin-18 antibody, Cytokeratin-19 antibody, Cytokeratin-8 antibody, K19 antibody, K8 antibody, Keratin, type I cytoskeletal 18 antibody, Keratin, type I cytoskeletal 19 antibody, Keratin, type II cytoskeletal 8 antibody, Keratin-18 antibody, Keratin-19 antibody, Keratin-8 antibody, KRT18 antibody, KRT19 antibody, KRT8 antibody, PIG46 antibody, Type-II keratin Kb8 antibody

Database links

UniProt/Swiss-Prot:P05783

Protein function

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. .

Protein tissue specificity

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. .

Involvement in disease

Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the intermediate filament family.

Protein post-translational modifications

Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. .; Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. .; O-GlcNAcylation increases solubility, and decreases stability by inducing proteasomal degradation.

Protein cellular localization

Cytoplasm, perinuclear region. Nucleus, nucleolus.

Research area

All research areas>Structural Proteins>Cytokeratin
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize Anti-Keratin 18 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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