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Mouse Monoclonal Anti-Ku70 antibody (STJ99222)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Ku70 antibody.
Check alternative names for the antibodyExpand
|5”-deoxyribose-5-phosphate lyase Ku70 antibody|5”-dRP lyase Ku70 antibody|70 kDa subunit of Ku antigen antibody|ATP dependent DNA helicase 2 subunit 1 antibody|ATP dependent DNA helicase II 70 kDa subunit antibody|ATP-dependent DNA helicase 2 subunit 1 antibody|ATP-dependent DNA helicase II 70 kDa subunit antibody|CTC box binding factor 75 kDa subunit antibody|CTC box-binding factor 75 kDa subunit antibody|CTC75 antibody|CTCBF antibody|DNA repair protein XRCC6 antibody|G22P1 antibody|Ku 70 antibody|Ku autoantigen p70 subunit antibody|Ku autoantigen, 70kDa antibody|Ku p70 antibody|Ku70 antibody|Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody|Kup70 antibody|Lupus Ku autoantigen protein p70 antibody|ML8 antibody|Thyroid autoantigen 70kD (Ku antigen) antibody|Thyroid autoantigen antibody|Thyroid lupus autoantigen antibody|Thyroid lupus autoantigen p70 antibody|Thyroid-lupus autoantigen antibody|TLAA antibody|X ray repair complementing defective repair in Chinese hamster cells 6 antibody|X-ray repair complementing defective repair in Chinese hamster cells 6 antibody|X-ray repair cross-complementing protein 6 antibody|XRCC 6 antibody|Xrcc6 antibody|XRCC6_HUMAN antibody|Anti-Ku70 antibody [N3H10] (ab3114)
SCBT cat No: sc-71470|sc-135963|sc-12729|sc-71469|sc-5309|sc-1486|sc-17789|sc-166386|sc-55505|sc-9033|sc-365766|sc-1487|sc-56129|sc-56130|sc-56131|sc-71471|sc-65575|
|Catalogue No.|| |
Anti-Ku70 antibody detects endogenous levels of Ku70 and does not cross-react with related proteins.
Purified recombinant human Ku70 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Ku70 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Ku70 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
5''-deoxyribose-5-phosphate lyase Ku70 antibody, 5''-dRP lyase Ku70 antibody, 70 kDa subunit of Ku antigen antibody, ATP dependent DNA helicase 2 subunit 1 antibody, ATP dependent DNA helicase II 70 kDa subunit antibody, ATP-dependent DNA helicase 2 subunit 1 antibody, ATP-dependent DNA helicase II 70 kDa subunit antibody, CTC box binding factor 75 kDa subunit antibody, CTC box-binding factor 75 kDa subunit antibody, CTC75 antibody, CTCBF antibody, DNA repair protein XRCC6 antibody, G22P1 antibody, Ku 70 antibody, Ku autoantigen p70 subunit antibody, Ku autoantigen, 70kDa antibody, Ku p70 antibody, Ku70 antibody, Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody, Kup70 antibody, Lupus Ku autoantigen protein p70 antibody, ML8 antibody, Thyroid autoantigen 70kD (Ku antigen) antibody, Thyroid autoantigen antibody, Thyroid lupus autoantigen antibody, Thyroid lupus autoantigen p70 antibody, Thyroid-lupus autoantigen antibody, TLAA antibody, X ray repair complementing defective repair in Chinese hamster cells 6 antibody, X-ray repair complementing defective repair in Chinese hamster cells 6 antibody, X-ray repair cross-complementing protein 6 antibody, XRCC 6 antibody, Xrcc6 antibody, XRCC6_HUMAN antibody
|Database links|| |
|Protein function|| |
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. .
|Protein sequence and domain|| |
Belongs to the ku70 family. ; Contains 1 Ku domain. ; Contains 1 SAP domain.
|Protein post-translational modifications|| |
Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair. .
|Protein cellular localization|| |
Nucleus . Chromosome .
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/Ku-Lupus-Antigen/">Ku Lupus Antigen</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"> (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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