Mouse Monoclonal Anti-Lamin B2 antibody (STJ99315)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-Lamin B2 antibody (STJ99315)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|LAMB 2 antibody|LAMB2 antibody|Lamin-B2 antibody|LMN 2 antibody|LMN B2 antibody|LMN2 antibody|LMNB 2 antibody|LMNB2 antibody|LMNB2_HUMAN antibody|MGC2721 antibody|RGD1563803 antibody|Anti-Lamin B2 antibody [LN43] (ab8983)
SCBT cat No: sc-71484|sc-377379|sc-56146|sc-133722|sc-56147|

Name

Anti-Lamin B2 antibody

Catalogue No.

STJ99315

Reactivity

Human, Mouse

Specificity

Anti-Lamin B2 antibody detects endogenous levels of Lamin B2 and does not cross-react with related proteins.

Immunogen

Recombinant human Lamin B2 protein.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

68kDa

Formulation

Anti-Lamin B2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Lamin B2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

LAMB 2 antibody, LAMB2 antibody, Lamin-B2 antibody, LMN 2 antibody, LMN B2 antibody, LMN2 antibody, LMNB 2 antibody, LMNB2 antibody, LMNB2_HUMAN antibody, MGC2721 antibody, RGD1563803 antibody

Database links

UniProt/Swiss-Prot:Q03252

Protein function

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Involvement in disease

Partial acquired lipodystrophy (APLD) [MIM:608709]: A rare childhood disease characterized by loss of subcutaneous fat from the face and trunk. Fat deposition on the pelvic girdle and lower limbs is normal or excessive. Most frequently, onset between 5 and 15 years of age. Most affected subjects are females and some show no other abnormality, but many develop glomerulonephritis, diabetes mellitus, hyperlipidemia, and complement deficiency. Mental retardation in some cases. APLD is a sporadic disorder of unknown etiology. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Epilepsy, progressive myoclonic 9 (EPM9) [MIM:616540]: An autosomal recessive form of progressive myoclonic epilepsy, a rare disease initially responsive to antiepileptic drugs which over time becomes refractory and can be associated with cognitive decline. EPM9 features include myoclonus, tonic-clonic seizures, ataxia, and psychomotor development. . Note=The disease may be caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the intermediate filament family. ; Contains 1 LTD domain.

Protein post-translational modifications

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

Protein cellular localization

Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.

Research area

All research areas>Tumor Suppressor/Apoptosis>Lamin
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize Anti-Lamin B2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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