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Mouse Monoclonal Anti-LC3A antibody (STJ99258)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-LC3A antibody.
Check alternative names for the antibodyExpand
|ATG8E antibody|LC3 antibody|LC3A antibody|MAP1 light chain 3 like protein 1 antibody|MAP1 light chain 3-like protein 1 antibody|MAP1A/1B light chain 3 A antibody|MAP1A/MAP1B LC3 A antibody|MAP1A/MAP1B light chain 3 A antibody|MAP1ALC3 antibody|MAP1BLC3 antibody|Map1lc3a antibody|Microtubule associated proteins 1A/1B light chain 3 antibody|Microtubule-associated protein 1 light chain 3 alpha antibody|Microtubule-associated proteins 1A and 1B, light chain 3 antibody|Microtubule-associated proteins 1A/1B light chain 3A antibody|MLP3A_HUMAN antibody|Anti-MAP1LC3A antibody [EP1983Y] – Autophagosome Marker (ab52768)
SCBT cat No: sc-134226|sc-16756|
|Catalogue No.|| |
Recombinant protein of human LC3A.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-LC3A antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-LC3A antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ATG8E antibody, LC3 antibody, LC3A antibody, MAP1 light chain 3 like protein 1 antibody, MAP1 light chain 3-like protein 1 antibody, MAP1A/1B light chain 3 A antibody, MAP1A/MAP1B LC3 A antibody, MAP1A/MAP1B light chain 3 A antibody, MAP1ALC3 antibody, MAP1BLC3 antibody, Map1lc3a antibody, Microtubule associated proteins 1A/1B light chain 3 antibody, Microtubule-associated protein 1 light chain 3 alpha antibody, Microtubule-associated proteins 1A and 1B, light chain 3 antibody, Microtubule-associated proteins 1A/1B light chain 3A antibody, MLP3A_HUMAN antibody
|Database links|| |
|Protein function|| |
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). .
|Protein tissue specificity|| |
Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. .
|Protein sequence and domain|| |
Belongs to the ATG8 family.
|Protein post-translational modifications|| |
The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094). .; The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine. .; Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity. .
|Protein cellular localization|| |
Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome . Note=LC3-II binds to the autophagic membranes.
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St John’s Laboratory Ltd.
|Product type|| |
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