Mouse Monoclonal Anti-MEK1 antibody (STJ99087)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-MEK1 antibody (STJ99087)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|Cardiofaciocutaneous syndrome antibody|CFC syndrome antibody|CFC4 antibody|Dual specificity mitogen activated protein kinase kinase 2 antibody|Dual specificity mitogen-activated protein kinase kinase 2 antibody|ERK activator kinase 2 antibody|FLJ26075 antibody|MAP kinase kinase 2 antibody|map2k2 antibody|MAPK / ERK kinase 2 antibody|MAPK/ERK kinase 2 antibody|MAPKK 2 antibody|MAPKK2 antibody|MEK 2 antibody|MEK2 antibody|Microtubule associated protein kinase kinase 2 antibody|Mitogen activated protein kinase kinase 2 antibody|Mitogen activated protein kinase kinase 2 p45 antibody|MKK 2 antibody|MKK2 antibody|MP2K2_HUMAN antibody|OTTHUMP00000165826 antibody|OTTHUMP00000165827 antibody|PRKMK 2 antibody|PRKMK2 antibody|Anti-MEK2 antibody [Y78] (ab32517)
SCBT cat No: sc-81473|sc-136261|sc-13159|sc-525|sc-524|sc-135985|sc-81474|

Name

Anti-MEK1 antibody

Catalogue No.

STJ99087

Reactivity

Human

Specificity

Anti-MEK1 antibody detects endogenous levels of MEK1/2 and does not cross-react with related proteins.

Immunogen

Recombinant human MEK1 protein.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

45kDa

Formulation

Anti-MEK1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-MEK1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Cardiofaciocutaneous syndrome antibody, CFC syndrome antibody, CFC4 antibody, Dual specificity mitogen activated protein kinase kinase 2 antibody, Dual specificity mitogen-activated protein kinase kinase 2 antibody, ERK activator kinase 2 antibody, FLJ26075 antibody, MAP kinase kinase 2 antibody, map2k2 antibody, MAPK / ERK kinase 2 antibody, MAPK/ERK kinase 2 antibody, MAPKK 2 antibody, MAPKK2 antibody, MEK 2 antibody, MEK2 antibody, Microtubule associated protein kinase kinase 2 antibody, Mitogen activated protein kinase kinase 2 antibody, Mitogen activated protein kinase kinase 2 p45 antibody, MKK 2 antibody, MKK2 antibody, MP2K2_HUMAN antibody, OTTHUMP00000165826 antibody, OTTHUMP00000165827 antibody, PRKMK 2 antibody, PRKMK2 antibody

Database links

UniProt/Swiss-Prot:P36507

Protein function

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). .

Involvement in disease

Cardiofaciocutaneous syndrome 4 (CFC4) [MIM:615280]: A form of cardiofaciocutaneous syndrome, a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. ; Contains 1 protein kinase domain.

Protein post-translational modifications

MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity). .; Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. .

Protein cellular localization

Cytoplasm . Membrane ; Peripheral membrane protein . Note=Membrane localization is probably regulated by its interaction with KSR1. .

Research area

All research areas>Kinases and Phosphatases>MEK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Anti-MEK1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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