Mouse Monoclonal Anti-NGAL antibody (STJ99274)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-NGAL antibody (STJ99274)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|24p3 antibody|HNL antibody|Lcn2 antibody|Lipocalin 2 antibody|Lipocalin-2 antibody|Migration stimulating factor inhibitor antibody|MSFI antibody|Neutrophil gelatinase-associated lipocalin antibody|NGAL antibody|NGAL_HUMAN antibody|Oncogene 24p3 antibody|p25 antibody|Siderocalin antibody|Siderocalin LCN2 antibody|Anti-Lipocalin-2 / NGAL antibody (ab63929)
SCBT cat No: sc-18698|sc-50351|

Name

Anti-NGAL antibody

Catalogue No.

STJ99274

Reactivity

Human

Immunogen

Recombinant protein of human NGAL.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2b

Molecular weight

23kDa

Formulation

Anti-NGAL antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-NGAL antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

24p3 antibody, HNL antibody, Lcn2 antibody, Lipocalin 2 antibody, Lipocalin-2 antibody, Migration stimulating factor inhibitor antibody, MSFI antibody, Neutrophil gelatinase-associated lipocalin antibody, NGAL antibody, NGAL_HUMAN antibody, Oncogene 24p3 antibody, p25 antibody, Siderocalin antibody, Siderocalin LCN2 antibody

Database links

UniProt/Swiss-Prot:P80188

Protein function

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. .

Protein tissue specificity

Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. .

Protein sequence and domain

Belongs to the calycin superfamily. Lipocalin family.

Protein cellular localization

Secreted . Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.

Note

AntibodyPlus can customize Anti-NGAL antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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