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Mouse Monoclonal Anti-NGAL antibody (STJ99274)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|24p3 antibody|HNL antibody|Lcn2 antibody|Lipocalin 2 antibody|Lipocalin-2 antibody|Migration stimulating factor inhibitor antibody|MSFI antibody|Neutrophil gelatinase-associated lipocalin antibody|NGAL antibody|NGAL_HUMAN antibody|Oncogene 24p3 antibody|p25 antibody|Siderocalin antibody|Siderocalin LCN2 antibody|Anti-Lipocalin-2 / NGAL antibody (ab63929)
SCBT cat No: sc-18698|sc-50351|
|Catalogue No.|| |
Recombinant protein of human NGAL.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-NGAL antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-NGAL antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
24p3 antibody, HNL antibody, Lcn2 antibody, Lipocalin 2 antibody, Lipocalin-2 antibody, Migration stimulating factor inhibitor antibody, MSFI antibody, Neutrophil gelatinase-associated lipocalin antibody, NGAL antibody, NGAL_HUMAN antibody, Oncogene 24p3 antibody, p25 antibody, Siderocalin antibody, Siderocalin LCN2 antibody
|Database links|| |
|Protein function|| |
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. .
|Protein tissue specificity|| |
Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. .
|Protein sequence and domain|| |
Belongs to the calycin superfamily. Lipocalin family.
|Protein cellular localization|| |
Secreted . Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.
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St John’s Laboratory Ltd.
|Product type|| |
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