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Mouse Monoclonal Anti-NUP98 antibody (STJ99140)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|96 kDa nucleoporin antibody|98 kDa nucleoporin antibody|ADAR2 antibody|ADIR2 antibody|GLFG-repeat containing nucleoporin antibody|Nuclear pore complex protein Nup96 antibody|Nuclear pore complex protein Nup98 Nup96 antibody|Nucleoporin 98kD antibody|nucleoporin 98kDa antibody|Nucleoporin Nup96 antibody|Nucleoporin Nup98 antibody|NUP196 antibody|NUP96 antibody|Nup98 antibody|Nup98-Nup96 antibody|NUP98_HUMAN antibody|Anti-NUP98 antibody [2H10] (ab50610)
SCBT cat No: sc-101546|sc-14155|sc-27400|sc-74578|sc-74553|sc-30112|
|Catalogue No.|| |
Anti-NUP98 antibody detects endogenous levels of NUP98 and does not cross-react with related proteins.
Purified recombinant human NUP98 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-NUP98 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-NUP98 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
96 kDa nucleoporin antibody, 98 kDa nucleoporin antibody, ADAR2 antibody, ADIR2 antibody, GLFG-repeat containing nucleoporin antibody, Nuclear pore complex protein Nup96 antibody, Nuclear pore complex protein Nup98 Nup96 antibody, Nucleoporin 98kD antibody, nucleoporin 98kDa antibody, Nucleoporin Nup96 antibody, Nucleoporin Nup98 antibody, NUP196 antibody, NUP96 antibody, Nup98 antibody, Nup98-Nup96 antibody, NUP98_HUMAN antibody
|Database links|| |
|Protein function|| |
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Nup98 and Nup96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. .
|Involvement in disease|| |
Note=A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23. .; Note=A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1. .; Note=A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1. .; Note=A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1. .; Note=A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. .; Note=A chromosomal aberration involving NUP98 has been identified in acute leukemias. Translocation t(6;11)(q24.1;p15.5) with CCDC28A. The chimeric transcript is an in-frame fusion of NUP98 exon 13 to CCDC28A exon 2. Ectopic expression of NUP98-CCDC28A in mouse promotes the proliferative capacity and self-renewal potential of hematopoietic progenitors and rapidly induced fatal myeloproliferative neoplasms and defects in the differentiation of the erythro-megakaryocytic lineage. .
|Protein sequence and domain|| |
Belongs to the nucleoporin GLFG family. ; Contains 1 peptidase S59 domain. Contains G-L-F-G repeats. The FG repeat domains in Nup98 have a direct role in the transport.
|Protein post-translational modifications|| |
Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96. .; Proteolytically degraded after poliovirus (PV) infection; degradation is partial and NCP- and TPR-binding domains withstand degradation.
|Protein cellular localization|| |
Nucleus membrane ; Peripheral membrane protein; Nucleoplasmic side . Nucleus, nuclear pore complex . Note=NUP98 is localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Detected in diffuse and discrete intranuclear foci (PubMed:11839768). Remained localized to the nuclear membrane after poliovirus (PV) infection. .
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St John’s Laboratory Ltd.
|Product type|| |
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