Mouse Monoclonal Anti-PKM2 antibody (STJ99144)

$99.00$319.00

Reactivity: Human, Mouse, Monkey
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-PKM2 antibody (STJ99144)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|CTHBP antibody|Cytosolic thyroid hormone binding protein antibody|Cytosolic thyroid hormone-binding protein antibody|KPYM_HUMAN antibody|MGC3932 antibody|OIP 3 antibody|OIP-3 antibody|OIP3 antibody|OPA interacting protein 3 antibody|Opa-interacting protein 3 antibody|p58 antibody|PK muscle type antibody|PK, muscle type antibody|PK2 antibody|PK3 antibody|PKM antibody|PKM2 antibody|pykm antibody|Pyruvate kinase 2/3 antibody|Pyruvate kinase 3 antibody|Pyruvate kinase isozymes M1/M2 antibody|Pyruvate kinase muscle antibody|Pyruvate kinase muscle isozyme antibody|pyruvate kinase PKM antibody|Pyruvate kinase, muscle 2 antibody|TCB antibody|THBP1 antibody|Thyroid hormone binding protein 1 antibody|Thyroid hormone binding protein cytosolic antibody|Thyroid hormone-binding protein 1 antibody|Tumor M2 PK antibody|Tumor M2-PK antibody|Anti-PKM2 antibody (ab38237)
SCBT cat No: sc-365684|sc-65176|sc-292640|sc-135048|sc-100538|

Name

Anti-PKM2 antibody

Catalogue No.

STJ99144

Reactivity

Human, Mouse, Monkey

Specificity

Anti-PKM2 antibody detects endogenous levels of PKM2 and does not cross-react with related proteins.

Immunogen

Purified recombinant human PKM2 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2b

Molecular weight

60kDa

Formulation

Anti-PKM2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-PKM2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

CTHBP antibody, Cytosolic thyroid hormone binding protein antibody, Cytosolic thyroid hormone-binding protein antibody, KPYM_HUMAN antibody, MGC3932 antibody, OIP 3 antibody, OIP-3 antibody, OIP3 antibody, OPA interacting protein 3 antibody, Opa-interacting protein 3 antibody, p58 antibody, PK muscle type antibody, PK, muscle type antibody, PK2 antibody, PK3 antibody, PKM antibody, PKM2 antibody, pykm antibody, Pyruvate kinase 2/3 antibody, Pyruvate kinase 3 antibody, Pyruvate kinase isozymes M1/M2 antibody, Pyruvate kinase muscle antibody, Pyruvate kinase muscle isozyme antibody, pyruvate kinase PKM antibody, Pyruvate kinase, muscle 2 antibody, TCB antibody, THBP1 antibody, Thyroid hormone binding protein 1 antibody, Thyroid hormone binding protein cytosolic antibody, Thyroid hormone-binding protein 1 antibody, Tumor M2 PK antibody, Tumor M2-PK antibody

Database links

UniProt/Swiss-Prot:P14618

Protein function

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. .

Protein tissue specificity

Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. .

Protein sequence and domain

Belongs to the pyruvate kinase family.

Protein post-translational modifications

ISGylated. .; Under hypoxia, hydroxylated by EGLN3. .; Acetylation at Lys-305 is stimulated by high glucose concentration, it decreases enzyme activity and promotes its lysosomal-dependent degradation via chaperone-mediated autophagy. .; FGFR1-dependent tyrosine phosphorylation is reduced by interaction with TRIM35. .

Protein cellular localization

Cytoplasm . Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.

Note

AntibodyPlus can customize Anti-PKM2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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