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Mouse Monoclonal Anti-PKM2 antibody (STJ99144)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-PKM2 antibody.
Check alternative names for the antibodyExpand
|CTHBP antibody|Cytosolic thyroid hormone binding protein antibody|Cytosolic thyroid hormone-binding protein antibody|KPYM_HUMAN antibody|MGC3932 antibody|OIP 3 antibody|OIP-3 antibody|OIP3 antibody|OPA interacting protein 3 antibody|Opa-interacting protein 3 antibody|p58 antibody|PK muscle type antibody|PK, muscle type antibody|PK2 antibody|PK3 antibody|PKM antibody|PKM2 antibody|pykm antibody|Pyruvate kinase 2/3 antibody|Pyruvate kinase 3 antibody|Pyruvate kinase isozymes M1/M2 antibody|Pyruvate kinase muscle antibody|Pyruvate kinase muscle isozyme antibody|pyruvate kinase PKM antibody|Pyruvate kinase, muscle 2 antibody|TCB antibody|THBP1 antibody|Thyroid hormone binding protein 1 antibody|Thyroid hormone binding protein cytosolic antibody|Thyroid hormone-binding protein 1 antibody|Tumor M2 PK antibody|Tumor M2-PK antibody|Anti-PKM2 antibody (ab38237)
SCBT cat No: sc-365684|sc-65176|sc-292640|sc-135048|sc-100538|
|Catalogue No.|| |
Human, Mouse, Monkey
Anti-PKM2 antibody detects endogenous levels of PKM2 and does not cross-react with related proteins.
Purified recombinant human PKM2 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-PKM2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-PKM2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
CTHBP antibody, Cytosolic thyroid hormone binding protein antibody, Cytosolic thyroid hormone-binding protein antibody, KPYM_HUMAN antibody, MGC3932 antibody, OIP 3 antibody, OIP-3 antibody, OIP3 antibody, OPA interacting protein 3 antibody, Opa-interacting protein 3 antibody, p58 antibody, PK muscle type antibody, PK, muscle type antibody, PK2 antibody, PK3 antibody, PKM antibody, PKM2 antibody, pykm antibody, Pyruvate kinase 2/3 antibody, Pyruvate kinase 3 antibody, Pyruvate kinase isozymes M1/M2 antibody, Pyruvate kinase muscle antibody, Pyruvate kinase muscle isozyme antibody, pyruvate kinase PKM antibody, Pyruvate kinase, muscle 2 antibody, TCB antibody, THBP1 antibody, Thyroid hormone binding protein 1 antibody, Thyroid hormone binding protein cytosolic antibody, Thyroid hormone-binding protein 1 antibody, Tumor M2 PK antibody, Tumor M2-PK antibody
|Database links|| |
|Protein function|| |
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. .
|Protein tissue specificity|| |
Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. .
|Protein sequence and domain|| |
Belongs to the pyruvate kinase family.
|Protein post-translational modifications|| |
ISGylated. .; Under hypoxia, hydroxylated by EGLN3. .; Acetylation at Lys-305 is stimulated by high glucose concentration, it decreases enzyme activity and promotes its lysosomal-dependent degradation via chaperone-mediated autophagy. .; FGFR1-dependent tyrosine phosphorylation is reduced by interaction with TRIM35. .
|Protein cellular localization|| |
Cytoplasm . Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.
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St John’s Laboratory Ltd.
|Product type|| |
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