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Mouse Monoclonal Anti-PP5 antibody (STJ99091)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-PP5 antibody.
Check alternative names for the antibodyExpand
|FLJ36922 antibody|FLJ55954 antibody|OTTHUMP00000165834 antibody|PP-T antibody|PP5 antibody|PPP5 antibody|PPP5_HUMAN antibody|Ppp5c antibody|PPT antibody|Protein phosphatase 5, catalytic subunit antibody|Protein phosphatase T antibody|Serine/threonine protein phosphatase 5 antibody|Serine/threonine-protein phosphatase 5 antibody|Anti-PP5 antibody (ab26053)
SCBT cat No: sc-136046|sc-32588|sc-32587|sc-271612|sc-271817|sc-271613|sc-515257|sc-271816|
|Catalogue No.|| |
Anti-PP5 antibody detects endogenous levels of PP5 and does not cross-react with related protein.
Purified recombinant human PP5 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-PP5 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-PP5 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
FLJ36922 antibody, FLJ55954 antibody, OTTHUMP00000165834 antibody, PP-T antibody, PP5 antibody, PPP5 antibody, PPP5_HUMAN antibody, Ppp5c antibody, PPT antibody, Protein phosphatase 5, catalytic subunit antibody, Protein phosphatase T antibody, Serine/threonine protein phosphatase 5 antibody, Serine/threonine-protein phosphatase 5 antibody
|Database links|| |
|Protein function|| |
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2. .
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. ; Contains 3 TPR repeats.
|Protein post-translational modifications|| |
Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form. .
|Protein cellular localization|| |
Nucleus . Cytoplasm . Cell membrane . Note=Predominantly nuclear (PubMed:15383005). But also present in the cytoplasm (PubMed:15383005). Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726). .
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St John’s Laboratory Ltd.
|Product type|| |
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