Mouse Monoclonal Anti-PP5 antibody (STJ99091)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-PP5 antibody (STJ99091)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|FLJ36922 antibody|FLJ55954 antibody|OTTHUMP00000165834 antibody|PP-T antibody|PP5 antibody|PPP5 antibody|PPP5_HUMAN antibody|Ppp5c antibody|PPT antibody|Protein phosphatase 5, catalytic subunit antibody|Protein phosphatase T antibody|Serine/threonine protein phosphatase 5 antibody|Serine/threonine-protein phosphatase 5 antibody|Anti-PP5 antibody (ab26053)
SCBT cat No: sc-136046|sc-32588|sc-32587|sc-271612|sc-271817|sc-271613|sc-515257|sc-271816|

Name

Anti-PP5 antibody

Catalogue No.

STJ99091

Reactivity

Human

Specificity

Anti-PP5 antibody detects endogenous levels of PP5 and does not cross-react with related protein.

Immunogen

Purified recombinant human PP5 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Molecular weight

57kDa

Formulation

Anti-PP5 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-PP5 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

FLJ36922 antibody, FLJ55954 antibody, OTTHUMP00000165834 antibody, PP-T antibody, PP5 antibody, PPP5 antibody, PPP5_HUMAN antibody, Ppp5c antibody, PPT antibody, Protein phosphatase 5, catalytic subunit antibody, Protein phosphatase T antibody, Serine/threonine protein phosphatase 5 antibody, Serine/threonine-protein phosphatase 5 antibody

Database links

UniProt/Swiss-Prot:P53041

Protein function

Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2. .

Protein tissue specificity

Ubiquitous. .

Protein sequence and domain

Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. ; Contains 3 TPR repeats.

Protein post-translational modifications

Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form. .

Protein cellular localization

Nucleus . Cytoplasm . Cell membrane . Note=Predominantly nuclear (PubMed:15383005). But also present in the cytoplasm (PubMed:15383005). Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726). .

Research area

All research areas>Kinases and Phosphatases>PP5
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Anti-PP5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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