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Mouse Monoclonal Anti-PPARgamma antibody (STJ99055)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-PPARgamma antibody.
Check alternative names for the antibodyExpand
|NR1C3 antibody|Nuclear receptor subfamily 1 group C member 3 antibody|Peroxisome proliferator-activated receptor gamma antibody|PPAR gamma antibody|PPAR-gamma antibody|PPARG antibody|PPARG_HUMAN antibody|PPARG1 antibody|PPARG2 antibody|Anti-PPAR gamma 1+2 antibody [A3409A] – ChIP Grade (ab41928)
SCBT cat No: sc-81152|sc-271392|sc-1981|sc-7273|sc-7196|sc-6285|sc-6284|sc-1984|sc-166731|sc-390740|sc-22020|sc-22022|sc-135704|
|Catalogue No.|| |
Anti-PPARgamma antibody detects endogenous levels of PPARgammaand does not cross-react with related proteins.
Purified recombinant human PPARgammaprotein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-PPARgamma antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-PPARgamma antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
NR1C3 antibody, Nuclear receptor subfamily 1 group C member 3 antibody, Peroxisome proliferator-activated receptor gamma antibody, PPAR gamma antibody, PPAR-gamma antibody, PPARG antibody, PPARG_HUMAN antibody, PPARG1 antibody, PPARG2 antibody
|Database links|| |
|Protein function|| |
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). .; (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. .
|Protein tissue specificity|| |
Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. .
|Involvement in disease|| |
Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer. .; Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. . Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.; Lipodystrophy, familial partial, 3 (FPLD3) [MIM:604367]: A form of lipodystrophy characterized by marked loss of subcutaneous fat from the extremities. Facial adipose tissue may be increased, decreased or normal. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Glioma 1 (GLM1) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. . Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
|Protein sequence and domain|| |
Belongs to the nuclear hormone receptor family. NR1 subfamily. ; Contains 1 nuclear receptor DNA-binding domain.
|Protein post-translational modifications|| |
O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes. .; Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By similarity). .
|Protein cellular localization|| |
Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation.
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St John’s Laboratory Ltd.
|Product type|| |
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