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Mouse Monoclonal Anti-Prominin-1 antibody (STJ99199)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Prominin-1 antibody.
Check alternative names for the antibodyExpand
|AC133 antibody|Antigen AC133 antibody|CD133 antibody|CORD12 antibody|Hematopoietic stem cell antigen antibody|hProminin antibody|MCDR2 antibody|MSTP061 antibody|OTTHUMP00000217744 antibody|OTTHUMP00000217745 antibody|OTTHUMP00000217746 antibody|PROM1 antibody|PROM1_HUMAN antibody|Prominin I antibody|Prominin like 1 antibody|Prominin like protein 1 precursor antibody|Prominin mouse like 1 antibody|Prominin-1 antibody|Prominin-like protein 1 antibody|Prominin1 antibody|PROML1 antibody|RP41 antibody|STGD4 antibody|Anti-CD133 antibody (ab19898)
SCBT cat No:
|Catalogue No.|| |
Anti-Prominin-1 antibody detects endogenous levels of Prominin-1 and does not cross-react with related proteins.
Purified recombinant human Prominin-1 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Prominin-1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Prominin-1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
AC133 antibody, Antigen AC133 antibody, CD133 antibody, CORD12 antibody, Hematopoietic stem cell antigen antibody, hProminin antibody, MCDR2 antibody, MSTP061 antibody, OTTHUMP00000217744 antibody, OTTHUMP00000217745 antibody, OTTHUMP00000217746 antibody, PROM1 antibody, PROM1_HUMAN antibody, Prominin I antibody, Prominin like 1 antibody, Prominin like protein 1 precursor antibody, Prominin mouse like 1 antibody, Prominin-1 antibody, Prominin-like protein 1 antibody, Prominin1 antibody, PROML1 antibody, RP41 antibody, STGD4 antibody
|Database links|| |
|Protein function|| |
May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439). .
|Protein tissue specificity|| |
Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level). .
|Involvement in disease|| |
Retinitis pigmentosa 41 (RP41) [MIM:612095]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Cone-rod dystrophy 12 (CORD12) [MIM:612657]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Stargardt disease 4 (STGD4) [MIM:603786]: A common hereditary macular degeneration. It is characterized by decreased central vision, atrophy of the macula and underlying retinal pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Retinal macular dystrophy 2 (MCDR2) [MIM:608051]: A bull’s-eye macular dystrophy characterized by bilateral annular atrophy of retinal pigment epithelium at the macula. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the prominin family.
|Protein post-translational modifications|| |
Isoform 1 and isoform 2 are glycosylated. .; Acetylation at Lys-225, Lys-257 and Lys-264 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis. .
|Protein cellular localization|| |
Apical cell membrane ; Multi-pass membrane protein . Cell projection, microvillus membrane ; Multi-pass membrane protein . Cell projection, cilium, photoreceptor outer segment . Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.
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St John’s Laboratory Ltd.
|Product type|| |
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