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Mouse Monoclonal Anti-Protein Phosphatase 4C antibody (STJ99049)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
|PP X antibody|PP-X antibody|Pp4 antibody|PP4C antibody|PP4C_HUMAN antibody|PPH3 antibody|PPP4 antibody|ppp4c antibody|PPX antibody|protein phosphatase 4 (formerly X), catalytic subunit antibody|Protein phosphatase 4 catalytic subunit antibody|Protein phosphatase X antibody|protein phosphatase X, catalytic subunit antibody|Serine/threonine protein phosphatase 4 catalytic subunit antibody|Serine/threonine-protein phosphatase 4 catalytic subunit antibody|Anti-PPP4C antibody [EPR19502] (ab195371)
SCBT cat No: sc-6118|sc-374106|
Anti-Protein Phosphatase 4C antibody
|Catalogue No.|| |
Anti-Protein Phosphatase 4C antibody detects endogenous levels of Protein Phosphatase 4C and does not cross-react with related proteins.
Purified recombinant human Protein Phosphatase 4C protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Protein Phosphatase 4C antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Protein Phosphatase 4C antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
PP X antibody, PP-X antibody, Pp4 antibody, PP4C antibody, PP4C_HUMAN antibody, PPH3 antibody, PPP4 antibody, ppp4c antibody, PPX antibody, protein phosphatase 4 (formerly X), catalytic subunit antibody, Protein phosphatase 4 catalytic subunit antibody, Protein phosphatase X antibody, protein phosphatase X, catalytic subunit antibody, Serine/threonine protein phosphatase 4 catalytic subunit antibody, Serine/threonine-protein phosphatase 4 catalytic subunit antibody
|Database links|| |
|Protein function|| |
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. .
|Protein sequence and domain|| |
Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
|Protein post-translational modifications|| |
Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair. .
|Protein cellular localization|| |
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/PPX/">PPX</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"> (View all antibody categories related to Kinases and Phosphatases)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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