Mouse Monoclonal Anti-Protein Phosphatase 4C antibody (STJ99049)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-Protein Phosphatase 4C antibody (STJ99049)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|PP X antibody|PP-X antibody|Pp4 antibody|PP4C antibody|PP4C_HUMAN antibody|PPH3 antibody|PPP4 antibody|ppp4c antibody|PPX antibody|protein phosphatase 4 (formerly X), catalytic subunit antibody|Protein phosphatase 4 catalytic subunit antibody|Protein phosphatase X antibody|protein phosphatase X, catalytic subunit antibody|Serine/threonine protein phosphatase 4 catalytic subunit antibody|Serine/threonine-protein phosphatase 4 catalytic subunit antibody|Anti-PPP4C antibody [EPR19502] (ab195371)
SCBT cat No: sc-6118|sc-374106|

Name

Anti-Protein Phosphatase 4C antibody

Catalogue No.

STJ99049

Reactivity

Human

Specificity

Anti-Protein Phosphatase 4C antibody detects endogenous levels of Protein Phosphatase 4C and does not cross-react with related proteins.

Immunogen

Purified recombinant human Protein Phosphatase 4C protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Molecular weight

34kDa

Formulation

Anti-Protein Phosphatase 4C antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Protein Phosphatase 4C antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

PP X antibody, PP-X antibody, Pp4 antibody, PP4C antibody, PP4C_HUMAN antibody, PPH3 antibody, PPP4 antibody, ppp4c antibody, PPX antibody, protein phosphatase 4 (formerly X), catalytic subunit antibody, Protein phosphatase 4 catalytic subunit antibody, Protein phosphatase X antibody, protein phosphatase X, catalytic subunit antibody, Serine/threonine protein phosphatase 4 catalytic subunit antibody, Serine/threonine-protein phosphatase 4 catalytic subunit antibody

Database links

UniProt/Swiss-Prot:P60510

Protein function

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. .

Protein sequence and domain

Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Protein post-translational modifications

Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair. .

Protein cellular localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Research area

All research areas>Kinases and Phosphatases>PPX
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Anti-Protein Phosphatase 4C antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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