Mouse Monoclonal Anti-Pyruvate Dehydrogenase E2 antibody (STJ99150)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-Pyruvate Dehydrogenase E2 antibody (STJ99150)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|70 kDa mitochondrial autoantigen of primary biliary cirrhosis antibody|Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex antibody|Dihydrolipoamide S Acetyltransferase antibody|Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex antibody|dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial antibody|DLAT antibody|DLTA antibody|E2 antibody|E2 component of pyruvate dehydrogenase complex antibody|M2 antigen complex 70 kDa subunit antibody|mitochondrial antibody|ODP2_HUMAN antibody|PBC antibody|PDC E2 antibody|PDC-E2 antibody|PDCE2 antibody|Pyruvate dehydrogenase complex component E2 antibody|Pyruvate dehydrogenase complex E2 subunit antibody|Anti-Pyruvate dehydrogenase E2/E3bp antibody [13G2AE2BH5] (ab110333)
SCBT cat No: sc-365276|sc-271534|sc-166899|sc-16892|sc-271352|sc-32925|sc-16890|

Name

Anti-Pyruvate Dehydrogenase E2 antibody

Catalogue No.

STJ99150

Reactivity

Human, Mouse

Specificity

Anti-Pyruvate Dehydrogenase E2 antibody detects endogenous levels of Pyruvate Dehydrogenase E2 and does not cross-react with related proteins.

Immunogen

Purified recombinant human Pyruvate Dehydrogenase E2 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

69kDa

Formulation

Anti-Pyruvate Dehydrogenase E2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Pyruvate Dehydrogenase E2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

70 kDa mitochondrial autoantigen of primary biliary cirrhosis antibody, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex antibody, Dihydrolipoamide S Acetyltransferase antibody, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex antibody, dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial antibody, DLAT antibody, DLTA antibody, E2 antibody, E2 component of pyruvate dehydrogenase complex antibody, M2 antigen complex 70 kDa subunit antibody, mitochondrial antibody, ODP2_HUMAN antibody, PBC antibody, PDC E2 antibody, PDC-E2 antibody, PDCE2 antibody, Pyruvate dehydrogenase complex component E2 antibody, Pyruvate dehydrogenase complex E2 subunit antibody

Database links

UniProt/Swiss-Prot:P10515

Protein function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

Involvement in disease

Note=Primary biliary cirrhosis is a chronic, progressive cholestatic liver disease characterized by the presence of antimitochondrial autoantibodies in patients’ serum. It manifests with inflammatory obliteration of intra-hepatic bile duct, leading to liver cell damage and cirrhosis. Patients with primary biliary cirrhosis show autoantibodies against the E2 component of pyruvate dehydrogenase complex.; Pyruvate dehydrogenase E2 deficiency (PDHE2 deficiency) [MIM:245348]: Pyruvate dehydrogenase (PDH) deficiency is a major cause of primary lactic acidosis and neurological dysfunction in infancy and early childhood. In this form of PDH deficiency episodic dystonia is the major neurological manifestation, with other more common features of pyruvate dehydrogenase deficiency, such as hypotonia and ataxia, being less prominent. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the 2-oxoacid dehydrogenase family. ; Contains 2 lipoyl-binding domains.

Protein post-translational modifications

Delipoylated at Lys-132 and Lys-259 by SIRT4, delipoylation decreases the PHD complex activity. .

Protein cellular localization

Mitochondrion matrix.

Research area

All research areas>Signaling Intermediates>PDC-E2
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize Anti-Pyruvate Dehydrogenase E2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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