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Mouse Monoclonal Anti-Pyruvate Dehydrogenase E2 antibody (STJ99150)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Pyruvate Dehydrogenase E2 antibody.
Check alternative names for the antibodyExpand
|70 kDa mitochondrial autoantigen of primary biliary cirrhosis antibody|Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex antibody|Dihydrolipoamide S Acetyltransferase antibody|Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex antibody|dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial antibody|DLAT antibody|DLTA antibody|E2 antibody|E2 component of pyruvate dehydrogenase complex antibody|M2 antigen complex 70 kDa subunit antibody|mitochondrial antibody|ODP2_HUMAN antibody|PBC antibody|PDC E2 antibody|PDC-E2 antibody|PDCE2 antibody|Pyruvate dehydrogenase complex component E2 antibody|Pyruvate dehydrogenase complex E2 subunit antibody|Anti-Pyruvate dehydrogenase E2/E3bp antibody [13G2AE2BH5] (ab110333)
SCBT cat No: sc-365276|sc-271534|sc-166899|sc-16892|sc-271352|sc-32925|sc-16890|
Anti-Pyruvate Dehydrogenase E2 antibody
|Catalogue No.|| |
Anti-Pyruvate Dehydrogenase E2 antibody detects endogenous levels of Pyruvate Dehydrogenase E2 and does not cross-react with related proteins.
Purified recombinant human Pyruvate Dehydrogenase E2 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Pyruvate Dehydrogenase E2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Pyruvate Dehydrogenase E2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
70 kDa mitochondrial autoantigen of primary biliary cirrhosis antibody, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex antibody, Dihydrolipoamide S Acetyltransferase antibody, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex antibody, dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial antibody, DLAT antibody, DLTA antibody, E2 antibody, E2 component of pyruvate dehydrogenase complex antibody, M2 antigen complex 70 kDa subunit antibody, mitochondrial antibody, ODP2_HUMAN antibody, PBC antibody, PDC E2 antibody, PDC-E2 antibody, PDCE2 antibody, Pyruvate dehydrogenase complex component E2 antibody, Pyruvate dehydrogenase complex E2 subunit antibody
|Database links|| |
|Protein function|| |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
|Involvement in disease|| |
Note=Primary biliary cirrhosis is a chronic, progressive cholestatic liver disease characterized by the presence of antimitochondrial autoantibodies in patients’ serum. It manifests with inflammatory obliteration of intra-hepatic bile duct, leading to liver cell damage and cirrhosis. Patients with primary biliary cirrhosis show autoantibodies against the E2 component of pyruvate dehydrogenase complex.; Pyruvate dehydrogenase E2 deficiency (PDHE2 deficiency) [MIM:245348]: Pyruvate dehydrogenase (PDH) deficiency is a major cause of primary lactic acidosis and neurological dysfunction in infancy and early childhood. In this form of PDH deficiency episodic dystonia is the major neurological manifestation, with other more common features of pyruvate dehydrogenase deficiency, such as hypotonia and ataxia, being less prominent. . Note=The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the 2-oxoacid dehydrogenase family. ; Contains 2 lipoyl-binding domains.
|Protein post-translational modifications|| |
Delipoylated at Lys-132 and Lys-259 by SIRT4, delipoylation decreases the PHD complex activity. .
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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