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Mouse Monoclonal Anti-Rad51 antibody (STJ99103)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Rad51 antibody.
Check alternative names for the antibodyExpand
|BRCA1/BRCA2 containing complex, subunit 5 antibody|BRCC 5 antibody|BRCC5 antibody|DNA repair protein RAD51 homolog 1 antibody|DNA repair protein rhp51 antibody|hRAD51 antibody|HsRAD51 antibody|HsT16930 antibody|MRMV2 antibody|Rad 51 antibody|RAD51 antibody|RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) antibody|RAD51 homolog A antibody|RAD51 homolog antibody|RAD51 recombinase antibody|RAD51, S. cerevisiae, homolog of antibody|RAD51_HUMAN antibody|RAD51A antibody|RECA antibody|RecA like protein antibody|RecA, E. coli, homolog of antibody|Recombination protein A antibody|Anti-Rad51 antibody (ab88572)
SCBT cat No: sc-53428|sc-56212|sc-6862|sc-398587|sc-377467|sc-8349|sc-56469|
|Catalogue No.|| |
Human, Mouse, Rat, Monkey
Anti-Rad51 antibody detects endogenous levels of Rad51 and does not cross-react with related proteins.
Recombinant protein of human Rad51.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Rad51 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Rad51 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
BRCA1/BRCA2 containing complex, subunit 5 antibody, BRCC 5 antibody, BRCC5 antibody, DNA repair protein RAD51 homolog 1 antibody, DNA repair protein rhp51 antibody, hRAD51 antibody, HsRAD51 antibody, HsT16930 antibody, MRMV2 antibody, Rad 51 antibody, RAD51 antibody, RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) antibody, RAD51 homolog A antibody, RAD51 homolog antibody, RAD51 recombinase antibody, RAD51, S. cerevisiae, homolog of antibody, RAD51_HUMAN antibody, RAD51A antibody, RECA antibody, RecA like protein antibody, RecA, E. coli, homolog of antibody, Recombination protein A antibody
|Database links|| |
|Protein function|| |
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028). .
|Protein tissue specificity|| |
Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.
|Involvement in disease|| |
Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; Mirror movements 2 (MRMV2) [MIM:614508]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Note=Defects in RAD51 have been found in patients with a Fanconi anemia-like phenotype. Disease features include growth retardation, microcephaly, mental retardation, radial dysplasia, thumb abnormalities, genital and renal defects, and hypersensitivity to DNA cross-linking agents and DNA damage. Affected individuals, however, do not show bone marrow failure and pediatric malignancies. .
|Protein sequence and domain|| |
Belongs to the RecA family. RAD51 subfamily. ; Contains 1 HhH domain. The nuclear localization may reside in the C-terminus (between 259 and 339 AA).
|Protein post-translational modifications|| |
Ubiquitinated by the SCF(FBXO18) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. .; Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function. .
|Protein cellular localization|| |
Nucleus . Cytoplasm . Cytoplasm, perinuclear region. Mitochondrion matrix . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner. .
|Research area|| |
<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Tumor-SuppressorApoptosis/">Tumor Suppressor/Apoptosis</a>><a href="http://antibodyplus.com/product-tag/Rad/">Rad</a><br><a href="http://antibodyplus.com/product-tag/Tumor-SuppressorApoptosis/"> (View all antibody categories related to Tumor Suppressor/Apoptosis)</a>
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St John’s Laboratory Ltd.
|Product type|| |
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