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Mouse Monoclonal Anti-RAD9A antibody (STJ99172)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-RAD9A antibody.
Check alternative names for the antibodyExpand
|Cell cycle checkpoint control protein antibody|Cell cycle checkpoint control protein RAD9A antibody|DNA repair exonuclease rad9 homolog A antibody|hRAD 9 antibody|hRAD9 antibody|Rad 9 antibody|RAD 9A antibody|RAD9 (S pombe) homolog antibody|RAD9 homolog A antibody|RAD9 homolog antibody|Rad9a antibody|RAD9A_HUMAN antibody|Anti-Rad9 antibody [93A535] (ab13600)
SCBT cat No: sc-136053|sc-74463|sc-166457|sc-74464|sc-10465|sc-8324|sc-32489|
|Catalogue No.|| |
Human, Mouse, Rat, Monkey
Anti-RAD9A antibody detects endogenous levels of RAD9A and does not cross-react with related proteins.
Purified recombinant human RAD9A protein fragments expressed in E.coli
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-RAD9A antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-RAD9A antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cell cycle checkpoint control protein antibody, Cell cycle checkpoint control protein RAD9A antibody, DNA repair exonuclease rad9 homolog A antibody, hRAD 9 antibody, hRAD9 antibody, Rad 9 antibody, RAD 9A antibody, RAD9 (S pombe) homolog antibody, RAD9 homolog A antibody, RAD9 homolog antibody, Rad9a antibody, RAD9A_HUMAN antibody
|Database links|| |
|Protein function|| |
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3′-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3′->5′ double stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. .
|Protein sequence and domain|| |
Belongs to the rad9 family.
|Protein post-translational modifications|| |
Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex. .
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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