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Mouse Monoclonal Anti-SHP-1 antibody (STJ99278)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-SHP-1 antibody.
Check alternative names for the antibodyExpand
|70Z-SHP antibody|EC 22.214.171.124 antibody|HCP antibody|HCPH antibody|Hematopoietic cell phosphatase antibody|Hematopoietic cell protein tyrosine phosphatase antibody|Hematopoietic cell protein-tyrosine phosphatase antibody|HPTP1C antibody|Protein tyrosine phosphatase 1C antibody|Protein tyrosine phosphatase non receptor type 6 antibody|Protein tyrosine phosphatase SHP1 antibody|Protein-tyrosine phosphatase 1C antibody|protein-tyrosine phosphatase SHP 1 antibody|Protein-tyrosine phosphatase SHP-1 antibody|PTN6_HUMAN antibody|PTP 1C antibody|PTP-1C antibody|PTP1C antibody|Ptpn6 antibody|SH PTP 1 antibody|SH PTP1 antibody|SH-PTP1 antibody|SHP 1 antibody|SHP 1L antibody|SHP1 antibody|SHP1L antibody|tyrosine protein phosphatase non receptor type 6 antibody|Tyrosine-protein phosphatase non-receptor type 6 antibody|Anti-SHP1 antibody [Y476] (ab32559)
SCBT cat No: sc-135780|sc-135781|sc-135782|sc-293147|sc-101798|sc-101799|sc-136227|sc-101087|sc-33371|sc-136094|sc-130857|
|Catalogue No.|| |
Anti-SHP-1 antibody detects endogenous levels of SHP-1 and does not cross-react with related proteins.
Purified recombinant human SHP-1 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-SHP-1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-SHP-1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
70Z-SHP antibody, EC 126.96.36.199 antibody, HCP antibody, HCPH antibody, Hematopoietic cell phosphatase antibody, Hematopoietic cell protein tyrosine phosphatase antibody, Hematopoietic cell protein-tyrosine phosphatase antibody, HPTP1C antibody, Protein tyrosine phosphatase 1C antibody, Protein tyrosine phosphatase non receptor type 6 antibody, Protein tyrosine phosphatase SHP1 antibody, Protein-tyrosine phosphatase 1C antibody, protein-tyrosine phosphatase SHP 1 antibody, Protein-tyrosine phosphatase SHP-1 antibody, PTN6_HUMAN antibody, PTP 1C antibody, PTP-1C antibody, PTP1C antibody, Ptpn6 antibody, SH PTP 1 antibody, SH PTP1 antibody, SH-PTP1 antibody, SHP 1 antibody, SHP 1L antibody, SHP1 antibody, SHP1L antibody, tyrosine protein phosphatase non receptor type 6 antibody, Tyrosine-protein phosphatase non-receptor type 6 antibody
|Database links|| |
|Protein function|| |
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. .
|Protein tissue specificity|| |
Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
|Protein sequence and domain|| |
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. ; Contains 2 SH2 domains. ; Contains 1 tyrosine-protein phosphatase domain. The N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the ligand-free close conformation.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity. .
|Protein cellular localization|| |
Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. .
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St John’s Laboratory Ltd.
|Product type|| |
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