Mouse Monoclonal Anti-SHP-1 antibody (STJ99278)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-SHP-1 antibody (STJ99278)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|70Z-SHP antibody|EC 3.1.3.48 antibody|HCP antibody|HCPH antibody|Hematopoietic cell phosphatase antibody|Hematopoietic cell protein tyrosine phosphatase antibody|Hematopoietic cell protein-tyrosine phosphatase antibody|HPTP1C antibody|Protein tyrosine phosphatase 1C antibody|Protein tyrosine phosphatase non receptor type 6 antibody|Protein tyrosine phosphatase SHP1 antibody|Protein-tyrosine phosphatase 1C antibody|protein-tyrosine phosphatase SHP 1 antibody|Protein-tyrosine phosphatase SHP-1 antibody|PTN6_HUMAN antibody|PTP 1C antibody|PTP-1C antibody|PTP1C antibody|Ptpn6 antibody|SH PTP 1 antibody|SH PTP1 antibody|SH-PTP1 antibody|SHP 1 antibody|SHP 1L antibody|SHP1 antibody|SHP1L antibody|tyrosine protein phosphatase non receptor type 6 antibody|Tyrosine-protein phosphatase non-receptor type 6 antibody|Anti-SHP1 antibody [Y476] (ab32559)
SCBT cat No: sc-135780|sc-135781|sc-135782|sc-293147|sc-101798|sc-101799|sc-136227|sc-101087|sc-33371|sc-136094|sc-130857|

Name

Anti-SHP-1 antibody

Catalogue No.

STJ99278

Reactivity

Human

Specificity

Anti-SHP-1 antibody detects endogenous levels of SHP-1 and does not cross-react with related proteins.

Immunogen

Purified recombinant human SHP-1 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Molecular weight

68kDa

Formulation

Anti-SHP-1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-SHP-1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

70Z-SHP antibody, EC 3.1.3.48 antibody, HCP antibody, HCPH antibody, Hematopoietic cell phosphatase antibody, Hematopoietic cell protein tyrosine phosphatase antibody, Hematopoietic cell protein-tyrosine phosphatase antibody, HPTP1C antibody, Protein tyrosine phosphatase 1C antibody, Protein tyrosine phosphatase non receptor type 6 antibody, Protein tyrosine phosphatase SHP1 antibody, Protein-tyrosine phosphatase 1C antibody, protein-tyrosine phosphatase SHP 1 antibody, Protein-tyrosine phosphatase SHP-1 antibody, PTN6_HUMAN antibody, PTP 1C antibody, PTP-1C antibody, PTP1C antibody, Ptpn6 antibody, SH PTP 1 antibody, SH PTP1 antibody, SH-PTP1 antibody, SHP 1 antibody, SHP 1L antibody, SHP1 antibody, SHP1L antibody, tyrosine protein phosphatase non receptor type 6 antibody, Tyrosine-protein phosphatase non-receptor type 6 antibody

Database links

UniProt/Swiss-Prot:P29350

Protein function

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. .

Protein tissue specificity

Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

Protein sequence and domain

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. ; Contains 2 SH2 domains. ; Contains 1 tyrosine-protein phosphatase domain. The N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the ligand-free close conformation.

Protein post-translational modifications

Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-564 enhances phosphatase activity. .

Protein cellular localization

Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. .

Research area

All research areas>Kinases and Phosphatases>SH-PTP
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Anti-SHP-1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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