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Mouse Monoclonal Anti-SIRT6 antibody (STJ99096)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-SIRT6 antibody.
Check alternative names for the antibodyExpand
|2810449N18Rik antibody|SIR2-like protein 6 antibody|SIR2L6 antibody|SIR6_HUMAN antibody|SIRT 6 antibody|SIRT6 antibody|Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody|Sirtuin 6 antibody|Sirtuin type 6 antibody|Sirtuin6 antibody|Anti-SIRT6 antibody – ChIP Grade (ab62739)
SCBT cat No:
|Catalogue No.|| |
Purified recombinant human SIRT6 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-SIRT6 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-SIRT6 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
2810449N18Rik antibody, SIR2-like protein 6 antibody, SIR2L6 antibody, SIR6_HUMAN antibody, SIRT 6 antibody, SIRT6 antibody, Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody, Sirtuin 6 antibody, Sirtuin type 6 antibody, Sirtuin6 antibody
|Database links|| |
|Protein function|| |
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. .
|Protein sequence and domain|| |
Belongs to the sirtuin family. Class IV subfamily. ; Contains 1 deacetylase sirtuin-type domain.
|Protein cellular localization|| |
Nucleus, nucleoplasm . Note=Predominantly nuclear. Associated with telomeric heterochromatin regions.
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St John’s Laboratory Ltd.
|Product type|| |
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