Mouse Monoclonal Anti-SIRT6 antibody (STJ99097)

$99.00$319.00

Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-SIRT6 antibody (STJ99097)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|2810449N18Rik antibody|SIR2-like protein 6 antibody|SIR2L6 antibody|SIR6_HUMAN antibody|SIRT 6 antibody|SIRT6 antibody|Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody|Sirtuin 6 antibody|Sirtuin type 6 antibody|Sirtuin6 antibody|Anti-SIRT6 antibody – ChIP Grade (ab62739)
SCBT cat No:

Name

Anti-SIRT6 antibody

Catalogue No.

STJ99097

Reactivity

Human, Mouse, Rat, Monkey

Specificity

Anti-SIRT6 antibody detects endogenous levels of SIRT6 and does not cross-react with related proteins.

Immunogen

Purified recombinant human SIRT6 protein expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

42kDa

Formulation

Anti-SIRT6 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-SIRT6 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

2810449N18Rik antibody, SIR2-like protein 6 antibody, SIR2L6 antibody, SIR6_HUMAN antibody, SIRT 6 antibody, SIRT6 antibody, Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody, Sirtuin 6 antibody, Sirtuin type 6 antibody, Sirtuin6 antibody

Database links

UniProt/Swiss-Prot:Q8N6T7

Protein function

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. .

Protein sequence and domain

Belongs to the sirtuin family. Class IV subfamily. ; Contains 1 deacetylase sirtuin-type domain.

Protein cellular localization

Nucleus, nucleoplasm . Note=Predominantly nuclear. Associated with telomeric heterochromatin regions.

Research area

All research areas>Signaling Intermediates>SIRT
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize Anti-SIRT6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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