Mouse Monoclonal Anti-SMARCC1 antibody (STJ99159)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-SMARCC1 antibody (STJ99159)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|AI115498 antibody|SWI3 antibody|Anti-SMARCC1 antibody (ab126180)
SCBT cat No: sc-32763|sc-48350|sc-137138|sc-365505|sc-365543|sc-10756|sc-9748|sc-9746|

Name

Anti-SMARCC1 antibody

Catalogue No.

STJ99159

Reactivity

Human

Specificity

Anti-SMARCC1 antibody detects endogenous levels of SMARCC1 and does not cross-react with related proteins.

Immunogen

Purified recombinant human SMARCC1 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

155kDa

Formulation

Anti-SMARCC1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-SMARCC1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

AI115498 antibody, SWI3 antibody

Database links

UniProt/Swiss-Prot:Q92922

Protein function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). .

Protein tissue specificity

Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas.

Protein sequence and domain

Belongs to the SMARCC family. ; Contains 1 SANT domain. ; Contains 1 SWIRM domain.

Protein post-translational modifications

Phosphorylated on undefined residues at the G2/M transition by ERK1 and other kinases. This may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein. .

Protein cellular localization

Nucleus.

Research area

All research areas>Transcription Regulators>BAF
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Anti-SMARCC1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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