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Mouse Monoclonal Anti-SMARCC1 antibody (STJ99159)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-SMARCC1 antibody.
Check alternative names for the antibodyExpand
|AI115498 antibody|SWI3 antibody|Anti-SMARCC1 antibody (ab126180)
SCBT cat No: sc-32763|sc-48350|sc-137138|sc-365505|sc-365543|sc-10756|sc-9748|sc-9746|
|Catalogue No.|| |
Anti-SMARCC1 antibody detects endogenous levels of SMARCC1 and does not cross-react with related proteins.
Purified recombinant human SMARCC1 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-SMARCC1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-SMARCC1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
AI115498 antibody, SWI3 antibody
|Database links|| |
|Protein function|| |
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). .
|Protein tissue specificity|| |
Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas.
|Protein sequence and domain|| |
Belongs to the SMARCC family. ; Contains 1 SANT domain. ; Contains 1 SWIRM domain.
|Protein post-translational modifications|| |
Phosphorylated on undefined residues at the G2/M transition by ERK1 and other kinases. This may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein. .
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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