Mouse Monoclonal Anti-Sox2 antibody (STJ99043)

$99.00$319.00

Reactivity: Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-Sox2 antibody (STJ99043)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|ANOP3 antibody|SRY-box 2 antibody|Transcription factor SOX 2 antibody|Transcription factor SOX-2 antibody|ysb antibody|Anti-SOX2 antibody (ab97959)
SCBT cat No:

Name

Anti-Sox2 antibody

Catalogue No.

STJ99043

Reactivity

Mouse

Specificity

Anti-Sox2 antibody detects endogenous levels of Sox2 and does not cross-react with related proteins.

Immunogen

Purified recombinant mouse Sox2 protein fragments expressed in E.coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

35kDa

Formulation

Anti-Sox2 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Sox2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

ANOP3 antibody, SRY-box 2 antibody, Transcription factor SOX 2 antibody, Transcription factor SOX-2 antibody, ysb antibody

Database links

UniProt/Swiss-Prot:P48431

Protein function

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). .

Involvement in disease

Microphthalmia, syndromic, 3 (MCOPS3) [MIM:206900]: A disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Contains 1 HMG box DNA-binding domain.

Protein post-translational modifications

Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. .

Protein cellular localization

Nucleus.

Research area

All research areas>Transcription Regulators>Sox
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Anti-Sox2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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