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Mouse Monoclonal Anti-SWAP70 antibody (STJ99160)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-SWAP70 antibody.
Check alternative names for the antibodyExpand
|KIAA0640 antibody|70kDa antibody|AV235546 antibody|FLJ39540 antibody|HSPC321 antibody|SWA 70 protein antibody|SWAP 70 antibody|SWAP switching B-cell complex 70kDa subunit antibody|SWAP-70 antibody|SWAP70 antibody|Switch associated protein 70 antibody|Switch-associated protein 70 antibody|SWP70_HUMAN antibody|Anti-SWAP70 antibody (ab150325)
SCBT cat No:
|Catalogue No.|| |
Human, Mouse, Rat, Monkey
Anti-SWAP70 antibody detects endogenous levels of SWAP70 and does not cross-react with related proteins.
Purified recombinant human SWAP70 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-SWAP70 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-SWAP70 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
KIAA0640 antibody, 70kDa antibody, AV235546 antibody, FLJ39540 antibody, HSPC321 antibody, SWA 70 protein antibody, SWAP 70 antibody, SWAP switching B-cell complex 70kDa subunit antibody, SWAP-70 antibody, SWAP70 antibody, Switch associated protein 70 antibody, Switch-associated protein 70 antibody, SWP70_HUMAN antibody
|Database links|| |
|Protein function|| |
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). .
|Protein tissue specificity|| |
Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760). .
|Protein sequence and domain|| |
Contains 1 PH domain. The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Cytoplasm . Cell membrane. Nucleus . Cell projection, lamellipodium . Cytoplasm, cytoskeleton . Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760). .
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St John’s Laboratory Ltd.
|Product type|| |
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