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Mouse Monoclonal Anti-Syntenin antibody (STJ99123)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Syntenin antibody.
Check alternative names for the antibodyExpand
|MDA-9 antibody|MDA9 antibody|Melanoma differentiation-associated protein 9 antibody|Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody|Scaffold protein Pbp1 antibody|SDCB1_HUMAN antibody|SDCBP antibody|ST1 antibody|SYCL antibody|Syndecan binding protein (syntenin) antibody|Syndecan binding protein 1 antibody|Syndecan-binding protein 1 antibody|Syntenin 1 antibody|Syntenin-1 antibody|TACIP18 antibody|Anti-Syntenin antibody [EPR8102] (ab133267)
SCBT cat No:
|Catalogue No.|| |
Anti-Syntenin antibody detects endogenous levels of Syntenin and does not cross-react with related proteins.
Purified recombinant human Syntenin protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
|Molecular weight|| |
Anti-Syntenin antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Syntenin antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
MDA-9 antibody, MDA9 antibody, Melanoma differentiation-associated protein 9 antibody, Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody, Scaffold protein Pbp1 antibody, SDCB1_HUMAN antibody, SDCBP antibody, ST1 antibody, SYCL antibody, Syndecan binding protein (syntenin) antibody, Syndecan binding protein 1 antibody, Syndecan-binding protein 1 antibody, Syntenin 1 antibody, Syntenin-1 antibody, TACIP18 antibody
|Database links|| |
|Protein function|| |
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). .
|Protein tissue specificity|| |
Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta. .
|Protein sequence and domain|| |
Contains 2 PDZ (DHR) domains.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues.
|Protein cellular localization|| |
Cell junction, focal adhesion . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus . Melanosome . Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Secreted, exosome . Membrane raft . Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
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St John’s Laboratory Ltd.
|Product type|| |
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