Mouse Monoclonal Anti-Syntenin antibody (STJ99123)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-Syntenin antibody (STJ99123)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|MDA-9 antibody|MDA9 antibody|Melanoma differentiation-associated protein 9 antibody|Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody|Scaffold protein Pbp1 antibody|SDCB1_HUMAN antibody|SDCBP antibody|ST1 antibody|SYCL antibody|Syndecan binding protein (syntenin) antibody|Syndecan binding protein 1 antibody|Syndecan-binding protein 1 antibody|Syntenin 1 antibody|Syntenin-1 antibody|TACIP18 antibody|Anti-Syntenin antibody [EPR8102] (ab133267)
SCBT cat No:

Name

Anti-Syntenin antibody

Catalogue No.

STJ99123

Reactivity

Human

Specificity

Anti-Syntenin antibody detects endogenous levels of Syntenin and does not cross-react with related proteins.

Immunogen

Purified recombinant human Syntenin protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2b

Molecular weight

32kDa

Formulation

Anti-Syntenin antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Syntenin antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

MDA-9 antibody, MDA9 antibody, Melanoma differentiation-associated protein 9 antibody, Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody, Scaffold protein Pbp1 antibody, SDCB1_HUMAN antibody, SDCBP antibody, ST1 antibody, SYCL antibody, Syndecan binding protein (syntenin) antibody, Syndecan binding protein 1 antibody, Syndecan-binding protein 1 antibody, Syntenin 1 antibody, Syntenin-1 antibody, TACIP18 antibody

Database links

UniProt/Swiss-Prot:O00560

Protein function

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). .

Protein tissue specificity

Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta. .

Protein sequence and domain

Contains 2 PDZ (DHR) domains.

Protein post-translational modifications

Phosphorylated on tyrosine residues.

Protein cellular localization

Cell junction, focal adhesion . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Nucleus . Melanosome . Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Secreted, exosome . Membrane raft . Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .

Research area

All research areas>Neurobiology>syntenin
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize Anti-Syntenin antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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