Mouse Monoclonal Anti-TBLR1 antibody (STJ99072)

$99.00$319.00

Reactivity: Human, Mouse
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-TBLR1 antibody (STJ99072)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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|C21 antibody||Anti-TBLR1 antibody – ChIP Grade (ab24550)
SCBT cat No:

Name

Anti-TBLR1 antibody

Catalogue No.

STJ99072

Reactivity

Human, Mouse

Specificity

Anti-TBLR1 antibody detects endogenous levels of TBLR1 and does not cross-react with related proteins.

Immunogen

Purified recombinant human TBLR1 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Molecular weight

60kDa

Formulation

Anti-TBLR1 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-TBLR1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

C21 antibody,

Database links

UniProt/Swiss-Prot:Q9BZK7

Protein function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. .

Protein tissue specificity

Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver. .

Involvement in disease

Pierpont syndrome (PRPTS) [MIM:602342]: An autosomal dominant syndrome characterized by multiple congenital anomalies, global developmental delay, learning disability, palmar and plantar fat pads, and distinctive facial characteristics, especially when smiling. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Mental retardation, autosomal dominant 41 (MRD41) [MIM:616944]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD41 patients manifest delayed psychomotor development, variable severity of intellectual disability, and delayed language. Non-specific dysmorphic features and autistic behavior is observed in some patients. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the WD repeat EBI family. ; Contains 1 F-box-like domain. ; Contains 1 LisH domain. ; Contains 8 WD repeats. The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.

Protein cellular localization

Nucleus .

Research area

All research areas>Steroid Receptors>TBL
(View all antibody categories related to Steroid Receptors)

Note

AntibodyPlus can customize Anti-TBLR1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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