Mouse Monoclonal Anti-TIF1gamma/TRIM33 antibody (STJ99067)

$99.00$319.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-TIF1gamma/TRIM33 antibody (STJ99067)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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|8030451N04Rik antibody|AI413936 antibody|cb1085 antibody|DKFZp586K1123 antibody|E3 ubiquitin-protein ligase TRIM33 antibody|EC 6.3.2.- antibody|Ectodermin antibody|Ectodermin homolog antibody|FLJ11429 antibody|FLJ32925 antibody|id:ibd2175 antibody|MGC136680 antibody|mKIAA1113 antibody|OTTHUMP00000013662 antibody|OTTHUMP00000013663 antibody|Protein Rfg7 antibody|PTC7 antibody|Ret fused gene 7 antibody|RET-fused gene 7 protein antibody|RFG7 antibody|Rfg7 protein antibody|TF1G antibody|TIF1-gamma antibody|TIF1G antibody|TIF1GAMMA antibody|TIFGAMMA antibody|Transcription intermediary factor 1-gamma antibody|Transcriptional intermediary factor 1 gamma antibody|TRI33_HUMAN antibody|trim33 antibody|Tripartite motif containing 33 antibody|Tripartite motif containing 33 protein antibody|tripartite motif-containing 33 antibody|Tripartite motif-containing protein 33 antibody|wu:fc17f10 antibody|zgc:136680 antibody|Anti-TIF1 gamma antibody [16G9] (ab33475)
SCBT cat No:

Name

Anti-TIF1gamma/TRIM33 antibody

Catalogue No.

STJ99067

Reactivity

Human

Specificity

Anti-TIF1gamma/TRIM33 antibody detects endogenous levels of TIF1 gamma / TRIM33 and does not cross-react with related proteins.

Immunogen

Purified recombinant human TIF1 gamma / TRIM33 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2a

Molecular weight

140kDa

Formulation

Anti-TIF1gamma/TRIM33 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-TIF1gamma/TRIM33 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

8030451N04Rik antibody, AI413936 antibody, cb1085 antibody, DKFZp586K1123 antibody, E3 ubiquitin-protein ligase TRIM33 antibody, EC 6.3.2.- antibody, Ectodermin antibody, Ectodermin homolog antibody, FLJ11429 antibody, FLJ32925 antibody, id:ibd2175 antibody, MGC136680 antibody, mKIAA1113 antibody, OTTHUMP00000013662 antibody, OTTHUMP00000013663 antibody, Protein Rfg7 antibody, PTC7 antibody, Ret fused gene 7 antibody, RET-fused gene 7 protein antibody, RFG7 antibody, Rfg7 protein antibody, TF1G antibody, TIF1-gamma antibody, TIF1G antibody, TIF1GAMMA antibody, TIFGAMMA antibody, Transcription intermediary factor 1-gamma antibody, Transcriptional intermediary factor 1 gamma antibody, TRI33_HUMAN antibody, trim33 antibody, Tripartite motif containing 33 antibody, Tripartite motif containing 33 protein antibody, tripartite motif-containing 33 antibody, Tripartite motif-containing protein 33 antibody, wu:fc17f10 antibody, zgc:136680 antibody

Database links

UniProt/Swiss-Prot:Q9UPN9

Protein function

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). .

Protein tissue specificity

Expressed in stem cells at the bottom of the crypts of the colon (at protein level). Expressed in colon adenomas and adenocarcinomas (at protein level). Expressed in brain, lung, liver, spleen, thymus, prostate, kidney, testis, heart, placenta, pancreas, small intestine, ovary, colon, skeletal muscle and hematopoietic progenitors.

Involvement in disease

Note=A chromosomal aberration involving TRIM33 is found in papillary thyroid carcinomas (PTCs). Translocation t(1;10)(p13;q11) with RET. The translocation generates the TRIM33/RET (PTC7) oncogene. .

Protein sequence and domain

Belongs to the TRIM/RBCC family. ; Contains 2 B box-type zinc fingers. ; Contains 1 bromo domain. ; Contains 1 PHD-type zinc finger. ; Contains 1 RING-type zinc finger.

Protein post-translational modifications

Sumoylated with SUMO1. .

Protein cellular localization

Nucleus . Note=In discrete nuclear dots resembling nuclear bodies. .

Research area

All research areas>Transcription Regulators>TIF1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize Anti-TIF1gamma/TRIM33 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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