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Mouse Monoclonal Anti-Toll-like Receptor 3 antibody (STJ99302)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000
Recommended protocols: check protocols
Click or hover above images to see image description for Anti-Toll-like Receptor 3 antibody.
Check alternative names for the antibodyExpand
|CD283 antibody|CD283 antigen antibody|IIAE2 antibody|TLR 3 antibody|Tlr3 antibody|TLR3_HUMAN antibody|Toll Like Receptor 3 antibody|Toll-like receptor 3 antibody|Anti-TLR3 antibody (ab62566)
SCBT cat No:
Anti-Toll-like Receptor 3 antibody
|Catalogue No.|| |
Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.
|Recommended dilution|| |
WB 1:500-2000; ELISA 1:10000-20000
Anti-Toll-like Receptor 3 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Anti-Toll-like Receptor 3 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
CD283 antibody, CD283 antigen antibody, IIAE2 antibody, TLR 3 antibody, Tlr3 antibody, TLR3_HUMAN antibody, Toll Like Receptor 3 antibody, Toll-like receptor 3 antibody
|Database links|| |
|Protein function|| |
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. .
|Protein tissue specificity|| |
Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. .
|Involvement in disease|| |
Herpes simplex encephalitis 2 (HSE2) [MIM:613002]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.
|Protein sequence and domain|| |
Belongs to the Toll-like receptor family. ; Contains 22 LRR (leucine-rich) repeats. ; Contains 1 LRRCT domain. ; Contains 1 LRRNT domain. ; Contains 1 TIR domain. ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18.
|Protein post-translational modifications|| |
Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding. .; TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes. .
|Protein cellular localization|| |
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome .
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St John’s Laboratory Ltd.
|Product type|| |
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