Mouse Monoclonal Anti-Toll-like Receptor 3 antibody (STJ99302)

$99.00$319.00

Reactivity: Transfected
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-Toll-like Receptor 3 antibody (STJ99302)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

|CD283 antibody|CD283 antigen antibody|IIAE2 antibody|TLR 3 antibody|Tlr3 antibody|TLR3_HUMAN antibody|Toll Like Receptor 3 antibody|Toll-like receptor 3 antibody|Anti-TLR3 antibody (ab62566)
SCBT cat No:

Name

Anti-Toll-like Receptor 3 antibody

Catalogue No.

STJ99302

Reactivity

Transfected

Immunogen

Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-2000; ELISA 1:10000-20000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG2b

Formulation

Anti-Toll-like Receptor 3 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration

1 mg/ml

Purification

Anti-Toll-like Receptor 3 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

CD283 antibody, CD283 antigen antibody, IIAE2 antibody, TLR 3 antibody, Tlr3 antibody, TLR3_HUMAN antibody, Toll Like Receptor 3 antibody, Toll-like receptor 3 antibody

Database links

UniProt/Swiss-Prot:O15455

Protein function

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. .

Protein tissue specificity

Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. .

Involvement in disease

Herpes simplex encephalitis 2 (HSE2) [MIM:613002]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. . Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.

Protein sequence and domain

Belongs to the Toll-like receptor family. ; Contains 22 LRR (leucine-rich) repeats. ; Contains 1 LRRCT domain. ; Contains 1 LRRNT domain. ; Contains 1 TIR domain. ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18.

Protein post-translational modifications

Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding. .; TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes. .

Protein cellular localization

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome .

Research area

All research areas>Membrane Receptors>TLR
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize Anti-Toll-like Receptor 3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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