Mouse Monoclonal Anti-UCHL1/PGP9.5 antibody (STJ99166)


Reactivity: Human, Monkey
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Anti-UCHL1/PGP9.5 antibody (STJ99166)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-2000; ELISA 1:10000-20000

Recommended protocols: check protocols

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Alternative names:

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SCBT cat No:


Anti-UCHL1/PGP9.5 antibody

Catalogue No.



Human, Monkey


Anti-UCHL1/PGP9.5 antibody detects endogenous levels of UCHL1 / PGP9.5 and does not cross-react with related proteins.


Purified recombinant human UCHL1 / PGP9.5 protein fragments expressed in E.coli.











Molecular weight



Anti-UCHL1/PGP9.5 antibody was tube-contained in liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.


1 mg/ml


Anti-UCHL1/PGP9.5 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Protein function

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. .

Protein tissue specificity

Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. .

Involvement in disease

Parkinson disease 5 (PARK5) [MIM:613643]: A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia. . Note=The disease is caused by mutations affecting the gene represented in this entry.; Neurodegeneration with optic atrophy, childhood-onset (NDGOA) [MIM:615491]: A progressive neurodegenerative syndrome characterized by childhood onset blindness, cerebellar ataxia, nystagmus, dorsal column dysfunction, and spasticity with upper motor neuron dysfunction. . Note=The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the peptidase C12 family.

Protein post-translational modifications

O-glycosylated. .

Protein cellular localization

Cytoplasm . Endoplasmic reticulum membrane ; Lipid-anchor . Note=About 30% of total UCHL1 is associated with membranes in brain.


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St John’s Laboratory Ltd.

Product type

Primary antibody


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