Mouse Monoclonal AP-1 antibody [4H9] (STJ97830)

$379.00

Reactivity: Human, Mouse
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal AP-1 antibody [4H9] (STJ97830)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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JUN antibody,|Activator protein 1 antibody|AP 1 antibody|DKFZp686C0818 antibody|FBJ murine osteosarcoma viral oncogene homolog B antibody|fosB antibody|FOSB_HUMAN antibody|G0/G1 switch regulatory protein 3 antibody|G0S3 antibody|GOS 3 antibody|GOS B antibody|GOS3 antibody|GOSB antibody|MGC42291 antibody|Oncogene FOS B antibody|Oncogene FOSB antibody|Protein fos B antibody|Protein fosB antibody|Anti-c-Jun antibody – ChIP Grade
SCBT cat No: sc-166540|sc-376488|sc-44|sc-74543|sc-1694|sc-45|sc-162685|sc-398286|sc-393629|sc-393544|sc-167469|sc-240235|sc-374394|sc-376355|

 

Name

AP-1 Monoclonal Antibody

Catalogue No.

STJ97830

Reactivity

Human, Mouse

Specificity

AP-1 Monoclonal Antibody detects endogenous levels of AP-1 protein.

Immunogen

Purified recombinant fragment of human AP-1 expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

AP-1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

AP-1 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Transcription factor AP-1 antibody, Activator protein 1 antibody, AP1 antibody, Proto-oncogene c-Jun antibody, V-jun avian sarcoma virus 17 oncogene homolog antibody, p39 antibody

Database links

Human UniProt/Swiss-Prot:P05412;Mouse UniPort/Swiss-Prot: P05627;Rat UniProt/Swiss-Port: P17325;Human Entrez Gene: 3725;Mouse Entrez Gene: 16476;Rat Entrez Gene: Rn.93714

Protein names

Transcription factor AP-1 , Activator protein 1 , AP1 , Proto-oncogene c-Jun , V-jun avian sarcoma virus 17 oncogene homolog , p39

Protein function

Transcription factor that recognizes and binds to the enhancer heptamer motif 5′-TGA[CG]TCA-3′. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells . Binds to the USP28 promoter in colorectal cancer (CRC) cells .

Protein sequence and domain

Belongs to the bZIP family. Jun subfamily. / Contains 1 bZIP (basic-leucine zipper) domain.

Protein post-translational modifications

Ubiquitinated by the SCF(FBXW7), leading to its degradation. Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7. / Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity. / Acetylated at Lys-271 by EP300.

Protein cellular localization

Nucleus

Research area

All research areas>Transport and Trafficking>Adaptin Related Adapter Protein
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus can customize AP-1 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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