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Mouse Monoclonal AP-1 antibody [5B1] (STJ97829)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
JUN antibody,|Activator protein 1 antibody|AP 1 antibody|DKFZp686C0818 antibody|FBJ murine osteosarcoma viral oncogene homolog B antibody|fosB antibody|FOSB_HUMAN antibody|G0/G1 switch regulatory protein 3 antibody|G0S3 antibody|GOS 3 antibody|GOS B antibody|GOS3 antibody|GOSB antibody|MGC42291 antibody|Oncogene FOS B antibody|Oncogene FOSB antibody|Protein fos B antibody|Protein fosB antibody|Anti-c-Jun antibody – ChIP Grade
SCBT cat No: sc-166540|sc-376488|sc-44|sc-74543|sc-1694|sc-45|sc-162685|sc-398286|sc-393629|sc-393544|sc-167469|sc-240235|sc-374394|sc-376355|
AP-1 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Monkey
AP-1 Monoclonal Antibody detects endogenous levels of AP-1 protein.
Purified recombinant fragment of human AP-1 expressed in E Coli
WB, IHC, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
AP-1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
AP-1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Transcription factor AP-1 antibody, Activator protein 1 antibody, AP1 antibody, Proto-oncogene c-Jun antibody, V-jun avian sarcoma virus 17 oncogene homolog antibody, p39 antibody
|Protein names|| |
Transcription factor AP-1 , Activator protein 1 , AP1 , Proto-oncogene c-Jun , V-jun avian sarcoma virus 17 oncogene homolog , p39
|Protein function|| |
Transcription factor that recognizes and binds to the enhancer heptamer motif 5′-TGA[CG]TCA-3′. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells . Binds to the USP28 promoter in colorectal cancer (CRC) cells .
|Protein sequence and domain|| |
Belongs to the bZIP family. Jun subfamily. / Contains 1 bZIP (basic-leucine zipper) domain.
|Protein post-translational modifications|| |
Ubiquitinated by the SCF(FBXW7), leading to its degradation. Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7. / Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity. / Acetylated at Lys-271 by EP300.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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