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Mouse Monoclonal ApoA-I antibody [5F4F5] (STJ97832)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
APOA1 antibody,|Apo-AI antibody|ApoA I antibody|ApoA-I antibody|APOA1 antibody|APOA1_HUMAN antibody|Apolipoprotein A-I(1-242) antibody|Apolipoprotein A1 antibody|Apolipoprotein AI antibody|Brp14 antibody|Ltw1 antibody|Lvtw1 antibody|Sep1 antibody|Sep2 antibody|Anti-Apolipoprotein A I antibody [EP1368Y] (ab52945)
SCBT cat No: sc-58230|sc-80551|sc-69755|sc-135837|sc-13549|sc-376818|sc-19029|sc-23605|
ApoA-I Monoclonal Antibody
|Catalogue No.|| |
ApoA-I Monoclonal Antibody detects endogenous levels of ApoA-I protein.
Purified recombinant fragment of human ApoA-I expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
ApoA-I Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
ApoA-I Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Apolipoprotein A-I antibody, Apo-AI antibody, ApoA-I antibody, Apolipoprotein A1 antibody
|Protein names|| |
Apolipoprotein A-I , Apo-AI , ApoA-I , Apolipoprotein A1
|Protein function|| |
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
|Protein tissue specificity|| |
Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.
|Involvement in disease|| |
High density lipoprotein deficiency 2 (HDLD2) [MIM:604091]: Inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux. Note: The disease is caused by mutations affecting the gene represented in this entry.; High density lipoprotein deficiency 1 (HDLD1) [MIM:205400]: Recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness. Note: The disease is caused by mutations affecting the gene represented in this entry.; Note: APOA1 mutations may be involved in the pathogenesis of amyloid polyneuropathy-nephropathy Iowa type, also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III (PubMed:3142462 and PubMed:2123470). The clinical picture is dominated by neuropathy in the early stages of the disease and nephropathy late in the course. Death is due in most cases to renal amyloidosis.; Amyloidosis 8 (AMYL8) [MIM:105200]: A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the apolipoprotein A1/A4/E family.
|Protein post-translational modifications|| |
Glycosylated. / Palmitoylated. / Phosphorylation sites are present in the extracellular medium.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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