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Mouse Monoclonal Arg antibody [1H1] (STJ97848)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
ABL2 antibody, ABLL antibody, ARG antibody,|Abelson murine leukemia viral oncogene homolog 2 antibody|Abelson tyrosine-protein kinase 2 antibody|ABL2 antibody|ABL2_HUMAN antibody|ABLL antibody|ARG antibody|Tyrosine kinase ARG antibody|Tyrosine protein kinase ABL2 antibody|Tyrosine-protein kinase ARG antibody|v abl Abelson murine leukemia viral oncogene homolog 2 antibody|Anti-ABL2 antibody (ab87987)
SCBT cat No: sc-81154|sc-6356|sc-20708|
Arg Monoclonal Antibody
|Catalogue No.|| |
Arg Monoclonal Antibody detects endogenous levels of Arg protein.
Purified recombinant fragment of Arg expressed in E Coli
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Arg Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Arg Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Abelson tyrosine-protein kinase 2 antibody, Abelson murine leukemia viral oncogene homolog 2 antibody, Abelson-related gene protein antibody, Tyrosine-protein kinase ARG antibody
|Protein names|| |
Abelson tyrosine-protein kinase 2 , Abelson murine leukemia viral oncogene homolog 2 , Abelson-related gene protein , Tyrosine-protein kinase ARG
|Protein function|| |
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Mg2+, Mn2+ / Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML). Phosphatidylinositol 4,5-bisphosphate (PIP2), a highly abundant phosphoinositide known to regulate cytoskeletal and membrane proteins, inhibits the tyrosine kinase activity (By similarity).
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Contains two distinct classes of F-actin-binding domains. Although both can bind F-actin, the 2 are required to bundle actin filaments (By similarity). / Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. / Contains 1 protein kinase domain. / Contains 1 SH2 domain. / Contains 1 SH3 domain.
|Protein post-translational modifications|| |
Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity). / Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.
|Protein cellular localization|| |
Cytoplasm > cytoskeleton
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St John’s Laboratory Ltd.
|Product type|| |
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