Mouse Monoclonal Arg antibody [1H1B11] (STJ97847)

$379.00

Reactivity: Human
Applications: WB, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Arg antibody [1H1B11] (STJ97847)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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ABL2 antibody, ABLL antibody, ARG antibody,|Abelson murine leukemia viral oncogene homolog 2 antibody|Abelson tyrosine-protein kinase 2 antibody|ABL2 antibody|ABL2_HUMAN antibody|ABLL antibody|ARG antibody|Tyrosine kinase ARG antibody|Tyrosine protein kinase ABL2 antibody|Tyrosine-protein kinase ARG antibody|v abl Abelson murine leukemia viral oncogene homolog 2 antibody|Anti-ABL2 antibody (ab87987)
SCBT cat No: sc-81154|sc-6356|sc-20708|

 

Name

Arg Monoclonal Antibody

Catalogue No.

STJ97847

Reactivity

Human

Specificity

Arg Monoclonal Antibody detects endogenous levels of Arg protein.

Immunogen

Purified recombinant fragment of Arg expressed in E Coli

Host

Mouse

Applications

WB, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Arg Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Arg Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Abelson tyrosine-protein kinase 2 antibody, Abelson murine leukemia viral oncogene homolog 2 antibody, Abelson-related gene protein antibody, Tyrosine-protein kinase ARG antibody

Database links

Human UniProt/Swiss-Prot:P42684;Rat UniProt/Swiss-Port: F1M0N1;Human Entrez Gene: 27;Mouse Entrez Gene: 11352;Rat Entrez Gene: Rn.69847

Protein names

Abelson tyrosine-protein kinase 2 , Abelson murine leukemia viral oncogene homolog 2 , Abelson-related gene protein , Tyrosine-protein kinase ARG

Protein function

Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Mg2+, Mn2+ / Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML). Phosphatidylinositol 4,5-bisphosphate (PIP2), a highly abundant phosphoinositide known to regulate cytoskeletal and membrane proteins, inhibits the tyrosine kinase activity (By similarity).

Protein tissue specificity

Widely expressed.

Protein sequence and domain

Contains two distinct classes of F-actin-binding domains. Although both can bind F-actin, the 2 are required to bundle actin filaments (By similarity). / Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. / Contains 1 protein kinase domain. / Contains 1 SH2 domain. / Contains 1 SH3 domain.

Protein post-translational modifications

Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB (By similarity). / Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.

Protein cellular localization

Cytoplasm > cytoskeleton

Research area

All research areas>Kinases and Phosphatases>Arg
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Arg Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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