Mouse Monoclonal Ataxin-1 antibody [2F5] (STJ97853)


Reactivity: Human
Applications: WB, IHC, IF, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal Ataxin-1 antibody [2F5] (STJ97853)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, FC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Ataxin-1 Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody


ATXN1 antibody, ATX1 antibody, SCA1 antibody,|alternative ataxin1 antibody|Ataxin-1 antibody|ATX1 antibody|ATX1_HUMAN antibody|Atxn1 antibody|D6S504E antibody|OTTHUMP00000016065 antibody|SCA1 antibody|Spinocerebellar ataxia type 1 protein antibody|Anti-Ataxin 1 antibody [S768] (ab186265)
SCBT cat No: sc-8766|sc-514953|sc-366868|sc-12526|



Ataxin-1 Monoclonal Antibody

Catalogue No.





Ataxin-1 Monoclonal Antibody detects endogenous levels of Ataxin-1 protein.


Purified recombinant fragment of human Ataxin-1 expressed in E Coli





Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000








Ataxin-1 Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.


1 mg/ml


Ataxin-1 Antibody was purified using affinity purification.


-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Ataxin-1 antibody, Spinocerebellar ataxia type 1 protein antibody

Database links

Human UniProt/Swiss-Prot:P54253;Mouse UniPort/Swiss-Prot: P54254;Rat UniProt/Swiss-Port: Q63540;Human Entrez Gene: 6310;Mouse Entrez Gene: 20238;Rat Entrez Gene: Rn.88438

Protein names

Ataxin-1 , Spinocerebellar ataxia type 1 protein

Protein function

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism.

Protein tissue specificity

Widely expressed throughout the body.

Involvement in disease

Spinocerebellar ataxia 1 (SCA1) [MIM:164400]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease. . Note: The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by expansion of the polyglutamine tract to about 40-83 repeats, causing accumulation in neurons and exerting toxicity. .

Protein sequence and domain

The AXH domain is required for interaction with CIC. / Belongs to the ATXN1 family. / Contains 1 AXH domain.

Protein post-translational modifications

Ubiquitinated by UBE3A, leading to its degradation by the proteasome. The presence of expanded poly-Gln repeats in spinocerebellar ataxia 1 (SCA1) patients impairs ubiquitination and degradation, leading to accumulation of ATXN1 in neurons and subsequent toxicity. / Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract. / Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.

Protein cellular localization

Cytoplasm / Nucleus

Research area

All research areas>Signaling Intermediates>Ataxin
(View all antibody categories related to Signaling Intermediates)


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St John’s Laboratory Ltd.

Product type

Primary antibody


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