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Mouse Monoclonal ATP-citrate synthase antibody (STJ98469)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, FC
Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500; FC 1:100-1:200
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
ACLY antibody,|ACL antibody|Acly antibody|ACLY_HUMAN antibody|ATP citrate (pro-S) lyase antibody|ATP citrate lyase antibody|ATP citrate synthase antibody|ATP-citrate (pro-S-)-lyase antibody|ATP-citrate synthase antibody|ATPcitrate synthase antibody|ATPCL antibody|Citrate cleavage enzyme antibody|CLATP antibody|OTTHUMP00000164773 antibody|Anti-ATP citrate lyase antibody [EP704Y] (ab40793)
SCBT cat No: sc-30538|sc-30537|sc-368656|sc-241869|sc-271614|
ATP-citrate synthase Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Cow, Chicken, Pig, Sheep
ATP-citrate synthase Monoclonal Antibody detects endogenous levels of ATP-citrate synthase protein.
Purified recombinant human ATP-citrate synthase (C-terminus) protein fragments expressed in Ecoli
WB, IF, FC
|Recommended dilution|| |
WB 1:1000-1:2000; IF 1:100-1:500; FC 1:100-1:200
ATP-citrate synthase Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
ATP-citrate synthase Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
ATP-citrate synthase antibody, ATP-citrate antibody, pro-S- antibody,-lyase antibody, ACL antibody, Citrate cleavage enzyme antibody
|Protein names|| |
ATP-citrate synthase , ATP-citrate , pro-S- ,-lyase , ACL , Citrate cleavage enzyme
|Protein function|| |
ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. / ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. / Mg2+ / Phosphorylation results in a 6-fold increase in V(max) and the conversion of citrate dependence from sigmoidal to hyperbolic. Fructose 6-phosphate (F6P) is also a potent activator.
|Protein sequence and domain|| |
In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. / In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. / Contains 1 ATP-grasp domain.
|Protein post-translational modifications|| |
ISGylated. / Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2. / Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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