Mouse Monoclonal ATP-citrate synthase antibody (STJ98469)

$379.00

Reactivity: Human, Mouse, Rat, Cow, Chicken, Pig, Sheep
Applications: WB, IF, FC
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal ATP-citrate synthase antibody (STJ98469)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IF, FC

Recommended dilution: WB 1:1000-1:2000; IF 1:100-1:500; FC 1:100-1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ACLY antibody,|ACL antibody|Acly antibody|ACLY_HUMAN antibody|ATP citrate (pro-S) lyase antibody|ATP citrate lyase antibody|ATP citrate synthase antibody|ATP-citrate (pro-S-)-lyase antibody|ATP-citrate synthase antibody|ATPcitrate synthase antibody|ATPCL antibody|Citrate cleavage enzyme antibody|CLATP antibody|OTTHUMP00000164773 antibody|Anti-ATP citrate lyase antibody [EP704Y] (ab40793)
SCBT cat No: sc-30538|sc-30537|sc-368656|sc-241869|sc-271614|

 

Name

ATP-citrate synthase Monoclonal Antibody

Catalogue No.

STJ98469

Reactivity

Human, Mouse, Rat, Cow, Chicken, Pig, Sheep

Specificity

ATP-citrate synthase Monoclonal Antibody detects endogenous levels of ATP-citrate synthase protein.

Immunogen

Purified recombinant human ATP-citrate synthase (C-terminus) protein fragments expressed in Ecoli

Host

Mouse

Applications

WB, IF, FC

Recommended dilution

WB 1:1000-1:2000; IF 1:100-1:500; FC 1:100-1:200

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

ATP-citrate synthase Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

ATP-citrate synthase Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

ATP-citrate synthase antibody, ATP-citrate antibody, pro-S- antibody,-lyase antibody, ACL antibody, Citrate cleavage enzyme antibody

Database links

Human UniProt/Swiss-Prot:P53396;Mouse UniPort/Swiss-Prot: Q91V92;Rat UniProt/Swiss-Port: P16638;Human Entrez Gene: 47;Mouse Entrez Gene: 104112;Rat Entrez Gene: Rn.29771

Protein names

ATP-citrate synthase , ATP-citrate , pro-S- ,-lyase , ACL , Citrate cleavage enzyme

Protein function

ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. / ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. / Mg2+ / Phosphorylation results in a 6-fold increase in V(max) and the conversion of citrate dependence from sigmoidal to hyperbolic. Fructose 6-phosphate (F6P) is also a potent activator.

Protein sequence and domain

In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. / In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. / Contains 1 ATP-grasp domain.

Protein post-translational modifications

ISGylated. / Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2. / Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site (Probable).

Protein cellular localization

Cytoplasm

Research area

All research areas>Synthesis and Degradation>Citrate synthase
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize ATP-citrate synthase Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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