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Mouse Monoclonal Axl antibody [7E10] (STJ97857)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Axl Monoclonal Antibody.
Check alternative names for the antibodyExpand
AXL antibody, UFO antibody,|AI323647 antibody|Ark antibody|Axl antibody|AXL oncogene antibody|AXL receptor tyrosine kinase antibody|AXL transforming gene antibody|AXL transforming sequence/gene antibody|EC 188.8.131.52 antibody|JTK11 antibody|Oncogene AXL antibody|Tyro7 antibody|Tyrosine protein kinase receptor UFO antibody|Tyrosine-protein kinase receptor UFO antibody|UFO antibody|UFO_HUMAN antibody|Anti-Axl antibody (ab37861)
SCBT cat No: sc-166268|sc-1096|sc-20741|sc-166269|sc-1097|
Axl Monoclonal Antibody
|Catalogue No.|| |
Axl Monoclonal Antibody detects endogenous levels of Axl protein.
Purified recombinant extracellular fragment of human Axl fused with hIgGFc tag expressed in HEK293 cell line
WB, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000
Axl Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Axl Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein kinase receptor UFO antibody, AXL oncogene antibody
|Protein names|| |
Tyrosine-protein kinase receptor UFO , AXL oncogene
|Protein function|| |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. / (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope . Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope . / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Activated by GAS6-binding and subsequent autophosphorylation.
|Protein tissue specificity|| |
Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
|Involvement in disease|| |
Note: AXL and its ligand GAS6 are highly expressed in thyroid carcinoma tissues, and might thus be involved in thyroid tumorigenesis. Overexpression of AXL and its ligand was also detected in many other cancers such as myeloproliferative disorders, prostatic carcinoma cells, or breast cancer.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. / Contains 2 fibronectin type-III domains. / Contains 2 Ig-like C2-type (immunoglobulin-like) domains. / Contains 1 protein kinase domain.
|Protein post-translational modifications|| |
Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion. / Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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