Mouse Monoclonal BACE antibody (STJ98471)

$379.00

Reactivity: Human, Rat, Cow, Dog, Pig
Applications: WB
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal BACE antibody (STJ98471)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB

Recommended dilution: WB 1:1000-1:2000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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BACE1 antibody, BACE antibody, KIAA1149 antibody,||
SCBT cat No: To be updated

 

Name

BACE Monoclonal Antibody

Catalogue No.

STJ98471

Reactivity

Human, Rat, Cow, Dog, Pig

Specificity

BACE Monoclonal Antibody detects endogenous levels of BACE protein.

Immunogen

Purified recombinant human BACE (C-terminus) protein fragments expressed in Ecoli

Host

Mouse

Applications

WB

Recommended dilution

WB 1:1000-1:2000

Clonality

Monoclonal

Conjugation

Unconjugated

Formulation

BACE Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Concentration

1 mg/ml

Purification

BACE Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Beta-secretase 1 antibody, Aspartyl protease 2 antibody, ASP2 antibody, Asp 2 antibody, Beta-site amyloid precursor protein cleaving enzyme 1 antibody, Beta-site APP cleaving enzyme 1 antibody, Memapsin-2 antibody, Membrane-associated aspartic protease 2 antibody

Database links

Human UniProt/Swiss-Prot:P56817;Mouse UniPort/Swiss-Prot: P56818;Rat UniProt/Swiss-Port: P56819;Human Entrez Gene: 23621;Mouse Entrez Gene: 23821;Rat Entrez Gene: Rn.207201

Protein names

Beta-secretase 1 , Aspartyl protease 2 , ASP2 , Asp 2 , Beta-site amyloid precursor protein cleaving enzyme 1 , Beta-site APP cleaving enzyme 1 , Memapsin-2 , Membrane-associated aspartic protease 2

Protein function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. / Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-, -Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer’s amyloid precursor protein. / Inhibited by RTN3 and RTN4.

Protein tissue specificity

Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.

Protein sequence and domain

The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP. / Belongs to the peptidase A1 family. / Contains 1 peptidase A1 domain.

Protein post-translational modifications

N-Glycosylated. / Acetylated in the endoplasmic reticulum at Lys-126, Lys-275, Lys-279, Lys-285, Lys-299, Lys-300 and Lys-307. Acetylation by NAT8 and NAT8B is transient and deacetylation probably occurs in the Golgi. Acetylation regulates the maturation, the transport to the plasma membrane, the stability and the expression of the protein.

Protein cellular localization

Membrane; Single-pass type I membrane protein / Golgi apparatus > trans-Golgi network / Endoplasmic reticulum / Endosome / Cell surface / Cytoplasmic vesicle membrane

Research area

All research areas>Neurobiology>BACE
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize BACE Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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