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Mouse Monoclonal Beclin-1 antibody (STJ98472)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB
Recommended dilution: WB 1:1000-1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Beclin-1 Monoclonal Antibody.
Check alternative names for the antibodyExpand
BECN1 antibody, GT197 antibody,|APG6 antibody|Bcl-2-interacting protein beclin antibody|Beclin-1 antibody|Beclin1 antibody|BECN 1 antibody|Becn1 antibody|BECN1_HUMAN antibody|Coiled coil myosin like BCL2 interacting protein antibody|Coiled-coil myosin-like BCL2-interacting protein antibody|GT197 antibody|Protein GT197 antibody|VPS 30 antibody|VPS30 antibody|Anti-Beclin 1 antibody (ab62557)
SCBT cat No: sc-10086|sc-48341|sc-48381|sc-11427|sc-10087|
Beclin-1 Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Pig, Rabbit
Beclin-1 Monoclonal Antibody detects endogenous levels of Beclin-1 protein.
Purified recombinant human Beclin-1 protein fragments expressed in Ecoli
|Recommended dilution|| |
Beclin-1 Antibody was tube-contained. Purified in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Beclin-1 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Beclin-1 antibody, Coiled-coil myosin-like BCL2-interacting protein antibody, Protein GT197 antibody
|Protein names|| |
Beclin-1 , Coiled-coil myosin-like BCL2-interacting protein , Protein GT197
|Protein function|| |
Plays a central role in autophagy . Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 . Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis . Protects against infection by a neurovirulent strain of Sindbis virus . May play a role in antiviral host defense. / Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
The coiled coil domain can form antiparallel homodimers and mediates dimerization with the coiled coil domains of ATG14 or UVRAG involved in the formation of PI3K complexes. / Belongs to the beclin family.
|Protein post-translational modifications|| |
Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy . In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy . / Polyubiquitinated by NEDD4, both with ‘Lys11’- and ‘Lys63’-linkages. ‘Lys’-11-linked poyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes. / Proteolytically processed by caspases including CASP8 and CASP3; the C-terminal fragments lack autophagy-inducing capacity and are proposed to induce apoptosis. Thus the cleavage is proposed to be an determinant to switch from autophagy to apoptosis pathways affecting cellular homeostasis including viral infections and survival of tumor cells.
|Protein cellular localization|| |
Cytoplasm / Golgi apparatus > trans-Golgi network membrane / Peripheral membrane protein / Endosome membrane / Peripheral membrane protein / Endoplasmic reticulum membrane / Peripheral membrane protein / Mitochondrion membrane / Peripheral membrane protein / Endosome / Cytoplasmic vesicle > autophagosome / Mitochondrion / Nucleus / Cytoplasm / Mitochondrion
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St John’s Laboratory Ltd.
|Product type|| |
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