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Mouse Monoclonal Blk antibody [9D10D1] (STJ97866)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC, ELISA
Recommended dilution: IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for Blk Monoclonal Antibody.
Check alternative names for the antibodyExpand
BLK antibody,|B lymphocyte kinase antibody|B lymphoid tyrosine kinase antibody|Blk antibody|BLK nonreceptor tyrosine kinase antibody|BLK_HUMAN antibody|EC 188.8.131.52 antibody|MGC 10442 antibody|MGC10442 antibody|MODY 11 antibody|MODY11 antibody|P55 BLK antibody|p55-BLK antibody|Tyrosine kinase B lymphocyte specific antibody|Tyrosine protein kinase antibody|Tyrosine-protein kinase BLK antibody|Phospho anti-BLK (Y501) antibody (ab111889)
SCBT cat No: sc-65939|sc-65980|sc-938|sc-393996|sc-376597|sc-393960|sc-329|
Blk Monoclonal Antibody
|Catalogue No.|| |
Blk Monoclonal Antibody detects endogenous levels of Blk protein.
Purified recombinant fragment of Blk expressed in E Coli
|Recommended dilution|| |
IHC 1:200-1:1000; ELISA 1:10000
Blk Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Blk Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein kinase Blk antibody, B lymphocyte kinase antibody, p55-Blk antibody
|Protein names|| |
Tyrosine-protein kinase Blk , B lymphocyte kinase , p55-Blk
|Protein function|| |
Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at ‘Tyr-188’and ‘Tyr-199’, as well as CD79B at ‘Tyr-196’ and ‘Tyr-207’. Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Antibody-mediated surface engagement of the B-cell antigen receptor (BCR) which results in the phosphorylation of BLK on tyrosine residues, stimulates the enzymatic activity.
|Protein tissue specificity|| |
Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.
|Involvement in disease|| |
Maturity-onset diabetes of the young 11 (MODY11) [MIM:613375]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. / Contains 1 protein kinase domain. / Contains 1 SH2 domain. / Contains 1 SH3 domain.
|Protein post-translational modifications|| |
Phosphorylated on tyrosine residues after antibody-mediated surface engagement of the B-cell antigen receptor (BCR). / Ubiquitination of activated BLK by the UBE3A ubiquitin protein ligase leads to its degradation by the ubiquitin-proteasome pathway.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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