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Mouse Monoclonal BLNK antibody [5G9] (STJ97870)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, FC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
BLNK antibody, BASH antibody, SLP65 antibody,|AGM4 antibody|B cell adapter containing SH2 domain protein antibody|B cell adapter containing Src homology 2 domain protein antibody|B cell adaptor containing SH2 domain antibody|B cell linker antibody|B cell linker protein antibody|B cell-specific adaptor protein antibody|B-cell activation antibody|B-cell adapter containing a SH2 domain protein antibody|B-cell adapter containing a Src homology 2 domain protein antibody|B-cell linker protein antibody|BASH antibody|Bca antibody|BLNK antibody|BLNK s antibody|BLNK_HUMAN antibody|Cytoplasmic adapter protein antibody|Ly 57 antibody|Ly57 antibody|Lymphocyte antigen 57 antibody|Lyw 57 antibody|Lyw57 antibody|MGC111051 antibody|SH2 domain-containing leukocyte protein, 65-KD antibody|SLP 65 antibody|SLP-65 antibody|SLP65 antibody|Src homology [SH2] domain-containing leukocyte protein of 65 kD antibody|Src homology 2 domain containing leukocyte protein of 65 kDa antibody|Src homology 2 domain-containing leukocyte protein of 65 kDa antibody|Anti-BLNK antibody [Y491] (ab32418)
SCBT cat No: sc-8003|sc-514780|sc-8382|sc-15345|sc-59459|
BLNK Monoclonal Antibody
|Catalogue No.|| |
BLNK Monoclonal Antibody detects endogenous levels of BLNK protein.
Purified recombinant fragment of human BLNK expressed in E Coli
WB, IHC, IF, FC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
BLNK Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
BLNK Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
B-cell linker protein antibody, B-cell adapter containing a SH2 domain protein antibody, B-cell adapter containing a Src homology 2 domain protein antibody, Cytoplasmic adapter protein antibody, Src homology 2 domain-containing leukocyte protein of 65 kDa antibody, SLP-65 antibody
|Protein names|| |
B-cell linker protein , B-cell adapter containing a SH2 domain protein , B-cell adapter containing a Src homology 2 domain protein , Cytoplasmic adapter protein , Src homology 2 domain-containing leukocyte protein of 65 kDa , SLP-65
|Protein function|| |
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
|Protein tissue specificity|| |
Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
|Involvement in disease|| |
Agammaglobulinemia 4, autosomal recessive (AGM4) [MIM:613502]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Contains 1 SH2 domain.
|Protein post-translational modifications|| |
Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca2+ and MAPK signaling pathways.
|Protein cellular localization|| |
Cytoplasm / Cell membrane
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St John’s Laboratory Ltd.
|Product type|| |
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