Mouse Monoclonal BMPR-II antibody [3F6] (STJ97877)

$379.00

Reactivity: Human, Mouse, Rat, Monkey
Applications: WB, IHC, IF, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal BMPR-II antibody [3F6] (STJ97877)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, IF, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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BMPR2 antibody, PPH1 antibody,|BMP type II receptor antibody|BMP type-2 receptor antibody|BMPR 2 antibody|BMPR 3 antibody|BMPR II antibody|BMPR-2 antibody|BMPR-II antibody|Bmpr2 antibody|BMPR2_HUMAN antibody|BMPR3 antibody|BMPRII antibody|BMR 2 antibody|BMR2 antibody|Bone morphogenetic protein receptor type 2 antibody|Bone morphogenetic protein receptor type II antibody|Bone morphogenetic protein receptor type-2 antibody|Bone morphogenic protein receptor type II serine threonine kinase antibody|BRK 3 antibody|BRK3 antibody|PPH 1 antibody|PPH1 antibody|Serine threonine kinase type II activin receptor like kinase antibody|T ALK antibody|TALK antibody|Type II activin receptor like kinase antibody|Anti-BMPR2 antibody (ab96826)
SCBT cat No: sc-393304|sc-5682|sc-130704|sc-20737|sc-5683|sc-73752|

 

Name

BMPR-II Monoclonal Antibody

Catalogue No.

STJ97877

Reactivity

Human, Mouse, Rat, Monkey

Specificity

BMPR-II Monoclonal Antibody detects endogenous levels of BMPR-II protein.

Immunogen

Purified recombinant fragment of human BMPR-II expressed in E Coli

Host

Mouse

Applications

WB, IHC, IF, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

BMPR-II Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

BMPR-II Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Bone morphogenetic protein receptor type-2 antibody, BMP type-2 receptor antibody, BMPR-2 antibody, Bone morphogenetic protein receptor type II antibody, BMP type II receptor antibody, BMPR-II antibody

Database links

Human UniProt/Swiss-Prot:Q13873;Mouse UniPort/Swiss-Prot: O35607;Rat UniProt/Swiss-Port: F1LQC5;Human Entrez Gene: 659;Mouse Entrez Gene: 12168;Rat Entrez Gene: Rn.40848

Protein names

Bone morphogenetic protein receptor type-2 , BMP type-2 receptor , BMPR-2 , Bone morphogenetic protein receptor type II , BMP type II receptor , BMPR-II

Protein function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. / ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. / Mg2+

Protein tissue specificity

Highly expressed in heart and liver.

Involvement in disease

Pulmonary hypertension, primary, 1 (PPH1) [MIM:178600]: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Pulmonary venoocclusive disease 1, autosomal dominant (PVOD1) [MIM:265450]: A disease characterized by widespread fibrous obstruction and intimal thickening of septal veins and preseptal venules, a low diffusing capacity for carbon monoxide, occult alveolar hemorrhage, and nodular ground-glass opacities, septal lines and lymph node enlargement showed by high-resolution computed tomography of the chest. It is frequently associated with pulmonary capillary dilatation and proliferation, and is a rare and devastating cause of pulmonary hypertension. . Note: The disease is caused by mutations affecting the gene represented in this entry.

Protein sequence and domain

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. / Contains 1 protein kinase domain.

Protein cellular localization

Cell membrane / Single-pass type I membrane protein

Research area

All research areas>Membrane Receptors>BMPR-II
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize BMPR-II Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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