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Mouse Monoclonal BMPR-II antibody [3F6] (STJ97877)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, IF, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
BMPR2 antibody, PPH1 antibody,|BMP type II receptor antibody|BMP type-2 receptor antibody|BMPR 2 antibody|BMPR 3 antibody|BMPR II antibody|BMPR-2 antibody|BMPR-II antibody|Bmpr2 antibody|BMPR2_HUMAN antibody|BMPR3 antibody|BMPRII antibody|BMR 2 antibody|BMR2 antibody|Bone morphogenetic protein receptor type 2 antibody|Bone morphogenetic protein receptor type II antibody|Bone morphogenetic protein receptor type-2 antibody|Bone morphogenic protein receptor type II serine threonine kinase antibody|BRK 3 antibody|BRK3 antibody|PPH 1 antibody|PPH1 antibody|Serine threonine kinase type II activin receptor like kinase antibody|T ALK antibody|TALK antibody|Type II activin receptor like kinase antibody|Anti-BMPR2 antibody (ab96826)
SCBT cat No: sc-393304|sc-5682|sc-130704|sc-20737|sc-5683|sc-73752|
BMPR-II Monoclonal Antibody
|Catalogue No.|| |
Human, Mouse, Rat, Monkey
BMPR-II Monoclonal Antibody detects endogenous levels of BMPR-II protein.
Purified recombinant fragment of human BMPR-II expressed in E Coli
WB, IHC, IF, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; ELISA 1:10000
BMPR-II Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
BMPR-II Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Bone morphogenetic protein receptor type-2 antibody, BMP type-2 receptor antibody, BMPR-2 antibody, Bone morphogenetic protein receptor type II antibody, BMP type II receptor antibody, BMPR-II antibody
|Protein names|| |
Bone morphogenetic protein receptor type-2 , BMP type-2 receptor , BMPR-2 , Bone morphogenetic protein receptor type II , BMP type II receptor , BMPR-II
|Protein function|| |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. / ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. / Mg2+
|Protein tissue specificity|| |
Highly expressed in heart and liver.
|Involvement in disease|| |
Pulmonary hypertension, primary, 1 (PPH1) [MIM:178600]: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. . Note: The disease is caused by mutations affecting the gene represented in this entry.; Pulmonary venoocclusive disease 1, autosomal dominant (PVOD1) [MIM:265450]: A disease characterized by widespread fibrous obstruction and intimal thickening of septal veins and preseptal venules, a low diffusing capacity for carbon monoxide, occult alveolar hemorrhage, and nodular ground-glass opacities, septal lines and lymph node enlargement showed by high-resolution computed tomography of the chest. It is frequently associated with pulmonary capillary dilatation and proliferation, and is a rare and devastating cause of pulmonary hypertension. . Note: The disease is caused by mutations affecting the gene represented in this entry.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. / Contains 1 protein kinase domain.
|Protein cellular localization|| |
Cell membrane / Single-pass type I membrane protein
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St John’s Laboratory Ltd.
|Product type|| |
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