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Mouse Monoclonal Bmx antibody [1C6] (STJ97878)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
BMX antibody,|Bmx antibody|BMX non receptor tyrosine kinase antibody|BMX_HUMAN antibody|BONE MARROW KINASE, X-LINKED antibody|Bone marrow tyrosine kinase gene in chromosome X protein antibody|Cytoplasmic tyrosine protein kinase BMX antibody|Cytoplasmic tyrosine-protein kinase BMX antibody|Epithelial and endothelial tyrosine kinase antibody|ETK antibody|NKT38 antibody|NTK 38 antibody|NTK38 antibody|Protein tyrosine kinase BMX antibody|PSCTK 2 antibody|PSCTK 3 antibody|PSCTK2 antibody|PSCTK3 antibody|Anti-BMX antibody (ab73887)
SCBT cat No: sc-136215|sc-8874|sc-376686|sc-271706|sc-271025|sc-20711|sc-8873|
Bmx Monoclonal Antibody
|Catalogue No.|| |
Bmx Monoclonal Antibody detects endogenous levels of Bmx protein.
Purified recombinant fragment of human Bmx expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
Bmx Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
Bmx Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Cytoplasmic tyrosine-protein kinase BMX antibody, Bone marrow tyrosine kinase gene in chromosome X protein antibody, Epithelial and endothelial tyrosine kinase antibody, ETK antibody, NTK38 antibody
|Protein names|| |
Cytoplasmic tyrosine-protein kinase BMX , Bone marrow tyrosine kinase gene in chromosome X protein , Epithelial and endothelial tyrosine kinase , ETK , NTK38
|Protein function|| |
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Zn2+ / TEK and vascular endothelial growth factor receptor 1 (FLT1) stimulate BMX tyrosine kinase activity (By similarity). Activated by integrins through the mediation of PTK2/FAK1. Activated by TNF through the mediation of TNFRSF1B.
|Protein tissue specificity|| |
Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.
|Protein sequence and domain|| |
SH2 domain mediates interaction with RUFY1. / Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. / Contains 1 Btk-type zinc finger. / Contains 1 PH domain. / Contains 1 protein kinase domain. / Contains 1 SH2 domain.
|Protein post-translational modifications|| |
Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to activation and is required for STAT3 phosphorylation by BMX.
|Protein cellular localization|| |
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St John’s Laboratory Ltd.
|Product type|| |
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