Mouse Monoclonal Bmx antibody [1C6] (STJ97878)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Mouse Monoclonal Bmx antibody [1C6] (STJ97878)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Bmx Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

BMX antibody,|Bmx antibody|BMX non receptor tyrosine kinase antibody|BMX_HUMAN antibody|BONE MARROW KINASE, X-LINKED antibody|Bone marrow tyrosine kinase gene in chromosome X protein antibody|Cytoplasmic tyrosine protein kinase BMX antibody|Cytoplasmic tyrosine-protein kinase BMX antibody|Epithelial and endothelial tyrosine kinase antibody|ETK antibody|NKT38 antibody|NTK 38 antibody|NTK38 antibody|Protein tyrosine kinase BMX antibody|PSCTK 2 antibody|PSCTK 3 antibody|PSCTK2 antibody|PSCTK3 antibody|Anti-BMX antibody (ab73887)
SCBT cat No: sc-136215|sc-8874|sc-376686|sc-271706|sc-271025|sc-20711|sc-8873|

 

Name

Bmx Monoclonal Antibody

Catalogue No.

STJ97878

Reactivity

Human

Specificity

Bmx Monoclonal Antibody detects endogenous levels of Bmx protein.

Immunogen

Purified recombinant fragment of human Bmx expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

Bmx Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

Bmx Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Cytoplasmic tyrosine-protein kinase BMX antibody, Bone marrow tyrosine kinase gene in chromosome X protein antibody, Epithelial and endothelial tyrosine kinase antibody, ETK antibody, NTK38 antibody

Database links

Human UniProt/Swiss-Prot:P51813;Mouse UniPort/Swiss-Prot: P97504;Human Entrez Gene: 660;Mouse Entrez Gene: 12169;Rat Entrez Gene: Rn.141648

Protein names

Cytoplasmic tyrosine-protein kinase BMX , Bone marrow tyrosine kinase gene in chromosome X protein , Epithelial and endothelial tyrosine kinase , ETK , NTK38

Protein function

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Zn2+ / TEK and vascular endothelial growth factor receptor 1 (FLT1) stimulate BMX tyrosine kinase activity (By similarity). Activated by integrins through the mediation of PTK2/FAK1. Activated by TNF through the mediation of TNFRSF1B.

Protein tissue specificity

Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.

Protein sequence and domain

SH2 domain mediates interaction with RUFY1. / Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. / Contains 1 Btk-type zinc finger. / Contains 1 PH domain. / Contains 1 protein kinase domain. / Contains 1 SH2 domain.

Protein post-translational modifications

Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to activation and is required for STAT3 phosphorylation by BMX.

Protein cellular localization

Cytoplasm

Research area

All research areas>Kinases and Phosphatases>Bmx
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize Bmx Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!