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Mouse Monoclonal c-Fgr antibody [6G2] (STJ97953)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, IHC, ELISA
Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
FGR antibody, SRC2 antibody,|c fgr antibody|c fgr protooncogene antibody|c src 2 proto oncogene antibody|c src2 antibody|Fgr antibody|FGR_HUMAN antibody|FLJ43153 antibody|Gardner Rasheed feline sarcoma viral (v fgr) antibody|Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog antibody|Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody|MGC75096 antibody|p55 c fgr protein antibody|P55 FGR antibody|P55-FGR antibody|p55c fgr antibody|p58-Fgr antibody|p58c fgr antibody|p58c-Fgr antibody|Proto oncogene c Fgr antibody|Proto oncogene tyrosine protein kinase FGR antibody|Proto-oncogene c-Fgr antibody|SRC 2 antibody|SRC2 antibody|Tyrosine protein kinase Fgr antibody|Tyrosine-protein kinase Fgr antibody|Anti-FGR antibody (ab153847)
SCBT cat No: sc-166079|sc-17|sc-514251|sc-74542|
c-Fgr Monoclonal Antibody
|Catalogue No.|| |
c-Fgr Monoclonal Antibody detects endogenous levels of c-Fgr protein.
Purified recombinant fragment of human c-Fgr expressed in E Coli
WB, IHC, ELISA
|Recommended dilution|| |
WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000
c-Fgr Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
c-Fgr Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein kinase Fgr antibody, Gardner-Rasheed feline sarcoma viral antibody, v-fgr antibody, oncogene homolog antibody, Proto-oncogene c-Fgr antibody, p55-Fgr antibody, p58-Fgr antibody, p58c-Fgr antibody
|Protein names|| |
Tyrosine-protein kinase Fgr , Gardner-Rasheed feline sarcoma viral , v-fgr , oncogene homolog , Proto-oncogene c-Fgr , p55-Fgr , p58-Fgr , p58c-Fgr
|Protein function|| |
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Activated by autophosphorylation. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412. Activated by phorbol myristate acetate, phosphatidic acid and poly-Lys. Binding (via SH2 domain) of HCLS1 that is already phosphorylated by SYK strongly increases kinase activity.
|Protein tissue specificity|| |
Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.
|Involvement in disease|| |
Note: Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. / Contains 1 protein kinase domain. / Contains 1 SH2 domain. / Contains 1 SH3 domain.
|Protein post-translational modifications|| |
Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation. / Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.
|Protein cellular localization|| |
Cell membrane / Cell membrane; Peripheral membrane protein; Cytoplasmic side / Cell projection > ruffle membrane / Cytoplasm > cytosol / Cytoplasm > cytoskeleton / Mitochondrion inner membrane / Mitochondrion intermembrane space
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St John’s Laboratory Ltd.
|Product type|| |
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