Mouse Monoclonal c-Fgr antibody [6G2] (STJ97953)

$379.00

Reactivity: Human, Mouse
Applications: WB, IHC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Mouse Monoclonal c-Fgr antibody [6G2] (STJ97953)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, IHC, ELISA

Recommended dilution: WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for c-Fgr Monoclonal Antibody.

Alternative names:

Check alternative names for the antibody

Expand

FGR antibody, SRC2 antibody,|c fgr antibody|c fgr protooncogene antibody|c src 2 proto oncogene antibody|c src2 antibody|Fgr antibody|FGR_HUMAN antibody|FLJ43153 antibody|Gardner Rasheed feline sarcoma viral (v fgr) antibody|Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog antibody|Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog antibody|MGC75096 antibody|p55 c fgr protein antibody|P55 FGR antibody|P55-FGR antibody|p55c fgr antibody|p58-Fgr antibody|p58c fgr antibody|p58c-Fgr antibody|Proto oncogene c Fgr antibody|Proto oncogene tyrosine protein kinase FGR antibody|Proto-oncogene c-Fgr antibody|SRC 2 antibody|SRC2 antibody|Tyrosine protein kinase Fgr antibody|Tyrosine-protein kinase Fgr antibody|Anti-FGR antibody (ab153847)
SCBT cat No: sc-166079|sc-17|sc-514251|sc-74542|

 

Name

c-Fgr Monoclonal Antibody

Catalogue No.

STJ97953

Reactivity

Human, Mouse

Specificity

c-Fgr Monoclonal Antibody detects endogenous levels of c-Fgr protein.

Immunogen

Purified recombinant fragment of human c-Fgr expressed in E Coli

Host

Mouse

Applications

WB, IHC, ELISA

Recommended dilution

WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

c-Fgr Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

c-Fgr Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tyrosine-protein kinase Fgr antibody, Gardner-Rasheed feline sarcoma viral antibody, v-fgr antibody, oncogene homolog antibody, Proto-oncogene c-Fgr antibody, p55-Fgr antibody, p58-Fgr antibody, p58c-Fgr antibody

Database links

Human UniProt/Swiss-Prot:P09769;Mouse UniPort/Swiss-Prot: P14234;Rat UniProt/Swiss-Port: Q6P6U0;Human Entrez Gene: 2268;Mouse Entrez Gene: 14191;Rat Entrez Gene: Rn.11309

Protein names

Tyrosine-protein kinase Fgr , Gardner-Rasheed feline sarcoma viral , v-fgr , oncogene homolog , Proto-oncogene c-Fgr , p55-Fgr , p58-Fgr , p58c-Fgr

Protein function

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. / Activated by autophosphorylation. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412. Activated by phorbol myristate acetate, phosphatidic acid and poly-Lys. Binding (via SH2 domain) of HCLS1 that is already phosphorylated by SYK strongly increases kinase activity.

Protein tissue specificity

Detected in neutrophils, monocytes and natural killer cells (at protein level). Detected in monocytes and large lymphocytes.

Involvement in disease

Note: Mutations that cause aberrant kinase activation can confer oncogene activity and promote aberrant cell proliferation.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. / Contains 1 protein kinase domain. / Contains 1 SH2 domain. / Contains 1 SH3 domain.

Protein post-translational modifications

Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation. / Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2A and/or FCGR2B engagement, cell adhesion and signaling by ITGB2. Prior phosphorylation at Tyr-523 by SRC inhibits ulterior autophosphorylation at Tyr-412.

Protein cellular localization

Cell membrane / Cell membrane; Peripheral membrane protein; Cytoplasmic side / Cell projection > ruffle membrane / Cytoplasm > cytosol / Cytoplasm > cytoskeleton / Mitochondrion inner membrane / Mitochondrion intermembrane space

Research area

All research areas>Kinases and Phosphatases>Fgr
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize c-Fgr Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!