Mouse Monoclonal c-Myc antibody [7E10] (STJ97962)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal c-Myc antibody [7E10] (STJ97962)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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MYC antibody, BHLHE39 antibody,|AU016757 antibody|MYC_HUMAN antibody|Myc2 antibody|MYCC antibody|Myelocytomatosis oncogene antibody|Niard antibody|Nird antibody|Oncogene Myc antibody|OTTHUMP00000158589 antibody|Proto-oncogene c-Myc antibody|Protooncogene homologous to myelocytomatosis virus antibody|RNCMYC antibody|Transcription factor p64 antibody|Transcriptional regulator Myc-A antibody|V-Myc avian myelocytomatosis viral oncogene homolog antibody|v-myc myelocytomatosis viral oncogene homolog (avian) antibody|Anti-cMyc antibody [Y69] (ab32072)
SCBT cat No: sc-70469|sc-53854|sc-40|sc-47694|sc-789|sc-398624|sc-788|sc-42|sc-41|sc-373712|sc-56634|sc-764|sc-56505|sc-74349|sc-390540|sc-74351|sc-74352|sc-51053|

 

Name

c-Myc Monoclonal Antibody

Catalogue No.

STJ97962

Reactivity

Human

Specificity

c-Myc Monoclonal Antibody detects endogenous levels of c-Myc protein.

Immunogen

Purified recombinant fragment of human c-Myc expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

c-Myc Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

c-Myc Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Myc proto-oncogene protein antibody, Class E basic helix-loop-helix protein 39 antibody, bHLHe39 antibody, Proto-oncogene c-Myc antibody, Transcription factor p64 antibody

Database links

Human UniProt/Swiss-Prot:P01106;Mouse UniPort/Swiss-Prot: P01108;Rat UniProt/Swiss-Port: P09416;Human Entrez Gene: 4609;Mouse Entrez Gene: 17869;Rat Entrez Gene: Rn.12072

Protein names

Myc proto-oncogene protein , Class E basic helix-loop-helix protein 39 , bHLHe39 , Proto-oncogene c-Myc , Transcription factor p64

Protein function

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5′-CAC[GA]TG-3′. Activates the transcription of growth-related genes.

Involvement in disease

Note: A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. .; Burkitt lymphoma (BL) [MIM:113970]: A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. . Note: The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.

Protein sequence and domain

Contains 1 bHLH (basic helix-loop-helix) domain.

Protein post-translational modifications

Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome. / Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).

Protein cellular localization

Nucleus > nucleoplasm / Nucleus > nucleolus

Research area

All research areas>Transcription Regulators>Myc
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize c-Myc Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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