Mouse Monoclonal c-Yes antibody [2F3E6] (STJ97980)

$379.00

Reactivity: Human
Applications: WB, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal c-Yes antibody [2F3E6] (STJ97980)

Supplier: St John’s Laboratory Ltd.

Recommended applications: WB, ELISA

Recommended dilution: WB 1:500-1:2000; ELISA 1:10000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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YES1 antibody, YES antibody,|c Yes antibody|Cellular Yes 1 protein antibody|Cellular Yes1 protein antibody|HsT441 antibody|P61 YES antibody|p61-Yes antibody|Proto oncogene tyrosine protein kinase YES antibody|Proto-oncogene c-Yes antibody|Tyrosine-protein kinase Yes antibody|v yes 1 Yamaguchi sarcoma viral oncogene homolog 1 antibody|Viral oncogene yes 1 homolog 1 antibody|Viral oncogene yes1 homolog 1 antibody|Yamaguchi sarcoma oncogene antibody|Yes 1 antibody|Yes antibody|YES proto oncogene 1, Src family tyrosine kinase antibody|YES_HUMAN antibody|YES1 antibody|YES1 proto oncogene, Src family tyrosine kinase antibody|Anti-Yes1 antibody [EPR3173] (ab109265)
SCBT cat No: sc-130055|sc-14|sc-515336|sc-46674|sc-48396|sc-8403|sc-515247|sc-28883|sc-49935|

 

Name

c-Yes Monoclonal Antibody

Catalogue No.

STJ97980

Reactivity

Human

Specificity

c-Yes Monoclonal Antibody detects endogenous levels of c-Yes protein.

Immunogen

Purified recombinant fragment of c-Yes (aa10-193) expressed in E Coli

Host

Mouse

Applications

WB, ELISA

Recommended dilution

WB 1:500-1:2000; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

c-Yes Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

c-Yes Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Tyrosine-protein kinase Yes antibody, Proto-oncogene c-Yes antibody, p61-Yes antibody

Database links

Human UniProt/Swiss-Prot:P07947;Mouse UniPort/Swiss-Prot: Q04736;Rat UniProt/Swiss-Port: Q6AXQ3;Human Entrez Gene: 7525;Mouse Entrez Gene: 22612;Rat Entrez Gene: Rn.214217

Protein names

Tyrosine-protein kinase Yes , Proto-oncogene c-Yes , p61-Yes

Protein function

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Protein tissue specificity

Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. / Contains 1 protein kinase domain. / Contains 1 SH2 domain. / Contains 1 SH3 domain.

Protein post-translational modifications

Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition. / Palmitoylation at Cys-3 promotes membrane localization.

Protein cellular localization

Cell membrane / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome / Cytoplasm > cytosol

Research area

All research areas>Kinases and Phosphatases>c-Yes
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize c-Yes Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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