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Mouse Monoclonal c-Yes antibody [2F3E6] (STJ97980)
Supplier: St John’s Laboratory Ltd.
Recommended applications: WB, ELISA
Recommended dilution: WB 1:500-1:2000; ELISA 1:10000
Recommended protocols: check protocols
Click or hover above images to see image description for c-Yes Monoclonal Antibody.
Check alternative names for the antibodyExpand
YES1 antibody, YES antibody,|c Yes antibody|Cellular Yes 1 protein antibody|Cellular Yes1 protein antibody|HsT441 antibody|P61 YES antibody|p61-Yes antibody|Proto oncogene tyrosine protein kinase YES antibody|Proto-oncogene c-Yes antibody|Tyrosine-protein kinase Yes antibody|v yes 1 Yamaguchi sarcoma viral oncogene homolog 1 antibody|Viral oncogene yes 1 homolog 1 antibody|Viral oncogene yes1 homolog 1 antibody|Yamaguchi sarcoma oncogene antibody|Yes 1 antibody|Yes antibody|YES proto oncogene 1, Src family tyrosine kinase antibody|YES_HUMAN antibody|YES1 antibody|YES1 proto oncogene, Src family tyrosine kinase antibody|Anti-Yes1 antibody [EPR3173] (ab109265)
SCBT cat No: sc-130055|sc-14|sc-515336|sc-46674|sc-48396|sc-8403|sc-515247|sc-28883|sc-49935|
c-Yes Monoclonal Antibody
|Catalogue No.|| |
c-Yes Monoclonal Antibody detects endogenous levels of c-Yes protein.
Purified recombinant fragment of c-Yes (aa10-193) expressed in E Coli
|Recommended dilution|| |
WB 1:500-1:2000; ELISA 1:10000
c-Yes Antibody was tube-contained. Ascitic fluid containing 0.03% sodium azide.
c-Yes Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Tyrosine-protein kinase Yes antibody, Proto-oncogene c-Yes antibody, p61-Yes antibody
|Protein names|| |
Tyrosine-protein kinase Yes , Proto-oncogene c-Yes , p61-Yes
|Protein function|| |
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. / ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
|Protein tissue specificity|| |
Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis.
|Protein sequence and domain|| |
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. / Contains 1 protein kinase domain. / Contains 1 SH2 domain. / Contains 1 SH3 domain.
|Protein post-translational modifications|| |
Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition. / Palmitoylation at Cys-3 promotes membrane localization.
|Protein cellular localization|| |
Cell membrane / Cytoplasm > cytoskeleton > microtubule organizing center > centrosome / Cytoplasm > cytosol
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St John’s Laboratory Ltd.
|Product type|| |
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