Mouse Monoclonal CD14 antibody [5A3] (STJ97905)

$379.00

Reactivity: Human
Applications: IHC, FC, ELISA
Conjugation: Unconjugated
Supplier: St John’s Laboratory Ltd.

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Mouse Monoclonal CD14 antibody [5A3] (STJ97905)

Supplier: St John’s Laboratory Ltd.

Recommended applications: IHC, FC, ELISA

Recommended dilution: IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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CD14 antibody,|CD 14 antibody|CD_antigen=CD14 antibody|CD14 antibody|CD14 antigen antibody|CD14 molecule antibody|CD14_HUMAN antibody|LPS-R antibody|Mo2 antibody|Monocyte differentiation antigen CD14 antibody|Monocyte differentiation antigen CD14 urinary form antibody|Monocyte differentiation antigen CD14, membrane-bound form antibody|Myeloid cell specific leucine rich glycoprotein antibody|Myeloid cell-specific leucine-rich glycoprotein antibody|Anti-CD14 antibody [EPR3653] (ab133335)
SCBT cat No: sc-58951|sc-52457|sc-7328|sc-6999|sc-9150|sc-6998|sc-5749|

 

Name

CD14 Monoclonal Antibody

Catalogue No.

STJ97905

Reactivity

Human

Specificity

CD14 Monoclonal Antibody detects endogenous levels of CD14 protein.

Immunogen

Purified recombinant fragment of human CD14 expressed in E Coli

Host

Mouse

Applications

IHC, FC, ELISA

Recommended dilution

IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000

Clonality

Monoclonal

Conjugation

Unconjugated

Isotype

IgG1

Formulation

CD14 Antibody was tube-contained. Purified antibody in PBS containing 0.03% sodium azide.

Concentration

1 mg/ml

Purification

CD14 Antibody was purified using affinity purification.

Storage

-20 Celsius degree. Avoid repeated freeze/thaw cycles.

Alternative antibody names

Monocyte differentiation antigen CD14 antibody, Myeloid cell-specific leucine-rich glycoprotein antibody, CD antigen CD14 antibody

Database links

Human UniProt/Swiss-Prot:P08571;Mouse UniPort/Swiss-Prot: P10810;Rat UniProt/Swiss-Port: Q63691;Human Entrez Gene: 929;Mouse Entrez Gene: 12475;Rat Entrez Gene: Rn.42942

Protein names

Monocyte differentiation antigen CD14 , Myeloid cell-specific leucine-rich glycoprotein , CD antigen CD14

Protein function

Coreceptor for bacterial lipopolysaccharide . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway . Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- .

Protein tissue specificity

Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

Protein sequence and domain

The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS. / Contains 11 LRR (leucine-rich) repeats.

Protein post-translational modifications

N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

Protein cellular localization

Cell membrane / Lipid-anchor > GPI-anchor / Secreted / Membrane raft / Golgi apparatus

Research area

All research areas>Lymphocyte Signaling>CD14
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize CD14 Antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provide antibody trial sample for your own antibody validation and collects antibody reviews.

Supplier

St John’s Laboratory Ltd.

Product type

Primary antibody

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