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Mouse Monoclonal CD14 antibody [5A3] (STJ97905)
Supplier: St John’s Laboratory Ltd.
Recommended applications: IHC, FC, ELISA
Recommended dilution: IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
CD14 antibody,|CD 14 antibody|CD_antigen=CD14 antibody|CD14 antibody|CD14 antigen antibody|CD14 molecule antibody|CD14_HUMAN antibody|LPS-R antibody|Mo2 antibody|Monocyte differentiation antigen CD14 antibody|Monocyte differentiation antigen CD14 urinary form antibody|Monocyte differentiation antigen CD14, membrane-bound form antibody|Myeloid cell specific leucine rich glycoprotein antibody|Myeloid cell-specific leucine-rich glycoprotein antibody|Anti-CD14 antibody [EPR3653] (ab133335)
SCBT cat No: sc-58951|sc-52457|sc-7328|sc-6999|sc-9150|sc-6998|sc-5749|
CD14 Monoclonal Antibody
|Catalogue No.|| |
CD14 Monoclonal Antibody detects endogenous levels of CD14 protein.
Purified recombinant fragment of human CD14 expressed in E Coli
IHC, FC, ELISA
|Recommended dilution|| |
IHC 1:200-1:1000; FC 1:200-1:400; ELISA 1:10000
CD14 Antibody was tube-contained. Purified antibody in PBS containing 0.03% sodium azide.
CD14 Antibody was purified using affinity purification.
-20 Celsius degree. Avoid repeated freeze/thaw cycles.
|Alternative antibody names|| |
Monocyte differentiation antigen CD14 antibody, Myeloid cell-specific leucine-rich glycoprotein antibody, CD antigen CD14 antibody
|Protein names|| |
Monocyte differentiation antigen CD14 , Myeloid cell-specific leucine-rich glycoprotein , CD antigen CD14
|Protein function|| |
Coreceptor for bacterial lipopolysaccharide . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway . Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL- .
|Protein tissue specificity|| |
Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
|Protein sequence and domain|| |
The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS. / Contains 11 LRR (leucine-rich) repeats.
|Protein post-translational modifications|| |
N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
|Protein cellular localization|| |
Cell membrane / Lipid-anchor > GPI-anchor / Secreted / Membrane raft / Golgi apparatus
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St John’s Laboratory Ltd.
|Product type|| |
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